Tyrer P, Seivewright N, Ferguson B, Tyrer J
Department of Community Psychiatry, St Charles Hospital, London, United Kingdom.
Acta Psychiatr Scand. 1992 Mar;85(3):201-6. doi: 10.1111/j.1600-0447.1992.tb08595.x.
The validity of the general neurotic syndrome, a combination of anxiety, depression and dependent personality disorder, was examined in a 2-year study of outpatients with dysthymic, panic and generalized anxiety disorder diagnosed using a structured interview schedule. The general neurotic syndrome, found in a third of the patients, was associated with greater mental disorder and a significantly worse outcome than patients without the syndrome. It did not, however, predict response to treatment. Further analysis revealed that the general neurotic syndrome was a better predictor of short- and long-term outcome than any other variable apart from initial psychopathology score. It is argued that the syndrome may represent a personality diathesis that makes the individual more vulnerable to both anxiety and depressive symptoms.
在一项为期两年的针对使用结构化访谈时间表诊断为恶劣心境、惊恐障碍和广泛性焦虑症的门诊患者的研究中，对由焦虑、抑郁和依赖型人格障碍组成的一般神经症综合征的有效性进行了检验。在三分之一的患者中发现了一般神经症综合征，与没有该综合征的患者相比，它与更严重的精神障碍和明显更差的预后相关。然而，它并不能预测对治疗的反应。进一步分析表明，除了初始精神病理学评分外，一般神经症综合征比任何其他变量都能更好地预测短期和长期预后。有人认为，该综合征可能代表一种人格素质，使个体更容易出现焦虑和抑郁症状。
