Worldwide Medicinal Chemistry, Pfizer, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6515-8. doi: 10.1016/j.bmcl.2011.08.071. Epub 2011 Aug 28.
A series of acidic triazoles with activity as soluble guanylate cyclase stimulators is described. Incorporation of the CF(3) triazole improved the overall physicochemical and drug-like properties of the molecule and is exemplified by compound 25.
本文描述了一系列具有可溶性鸟苷酸环化酶刺激活性的酸性三唑类化合物。CF(3)三唑的引入改善了分子的整体物理化学和药物样性质，化合物 25 就是一个例证。
