一种通过衣康酰亚胺的环化反应合成氢化咪唑并[1,5 - ]哒嗪的新方法及反应途径的HPLC - HRMS监测
A novel synthetic approach to hydroimidazo[1,5-]pyridazines by the recyclization of itaconimides and HPLC-HRMS monitoring of the reaction pathway.
作者信息
Vandyshev Dmitry Yu, Shikhaliev Khidmet S, Potapov Andrey Yu, Krysin Michael Yu, Zubkov Fedor I, Sapronova Lyudmila V
机构信息
Faculty of Chemistry, Voronezh State University, Universitetskaya sq., 1, Voronezh 394018, Russian Federation.
Faculty of Physics and Mathematics and Natural Sciences, RUDN University, Miklukho-Maklaya St., 6, Moscow 117198, Russian Federation.
出版信息
Beilstein J Org Chem. 2017 Nov 30;13:2561-2568. doi: 10.3762/bjoc.13.252. eCollection 2017.
The novel cascade two-stage reaction between itaconimides and 1,2-diamino-4-phenylimidazole proceeds regio- and chemoselectively to form tetrahydroimidazo[1,5-]pyridazines and includes nucleophilic C-addition by the activated C=C double bond and subsequent intramolecular recyclization of the intermediate with the amino group involved.
衣康酰亚胺与1,2-二氨基-4-苯基咪唑之间的新型串联两步反应区域选择性和化学选择性地进行，生成四氢咪唑并[1,5 -]哒嗪，包括活化的C = C双键进行亲核C加成以及随后中间体与相关氨基的分子内环化。
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