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胎儿脑积水。

Fetal hydrocephalus.

作者信息

Cavalheiro Sergio, Moron Antonio Fernandes, Almodin Carlos Gilberto, Suriano Italo Capraro, Hisaba Vagner, Dastoli Patricia, Barbosa Mauricio Mendes

机构信息

Section of Pediatric Neurosurgery, Federal University of São Paulo, Rua Botucatu 591/42, 04023-062 São Paulo, Brazil.

出版信息

Childs Nerv Syst. 2011 Oct;27(10):1575-83. doi: 10.1007/s00381-011-1539-1. Epub 2011 Sep 17.

Abstract

INTRODUCTION

Hydrocephalus is the most frequent and devastating illness affecting a fetus. The development of both ultrasonography and magnetic resonance, associated with laboratorial tests, has greatly facilitated its diagnosis.

MATERIALS AND METHODS

In the Fetal Medicine Service of the Federal University of São Paulo and in the Santa Joana/Pro-Matre Paulista Hospital Complex, in São Paulo, SP, Brazil, repeated cephalocenteses, ventricular-amniotic shunting, and neuroendoscopy were used to treat 57 fetuses with hydrocephalus, all of them at a gestational age under 32 weeks. Another eight fetuses had myelomeningocele and underwent correctional open surgery to prevent hydrocephalus.

RESULTS

Thirty-nine patients were followed up for a period longer than 3 years and had their intelligence coefficient assessed: 26 of them were considered normal (IQ above 70); six had mild or moderate handicaps (IQ from 35 to 70), and seven were severely handicapped (IQ below 35). Out of the eight patients operated for correction of myelomeningocele, only two came to require shunting. There were no cases of maternal morbidity, and no infectious condition was observed in any of the patients subjected to intrauterine treatment.

CONCLUSION

Selected cases of isolated, evolutive, non-destructive hydrocephaly diagnosed before 32 gestational weeks may benefit from fetal neurosurgical procedures. With the accuracy improvement of diagnoses, the number of patients fitting into that group has become very small.

摘要

引言

脑积水是影响胎儿的最常见且最具破坏性的疾病。超声检查和磁共振成像技术的发展,再结合实验室检查,极大地促进了该病的诊断。

材料与方法

在巴西圣保罗州圣保罗市的圣保罗联邦大学胎儿医学科以及圣若阿娜/圣保罗圣母医院综合大楼,对57例孕周小于32周的脑积水胎儿采用重复头颅穿刺、脑室-羊膜分流术和神经内镜进行治疗。另外8例患有脊髓脊膜膨出的胎儿接受了矫正性开放手术以预防脑积水。

结果

39例患者接受了超过3年的随访并评估了智力系数:其中26例被认为正常(智商高于70);6例有轻度或中度残疾(智商为35至70),7例有严重残疾(智商低于35)。在8例接受脊髓脊膜膨出矫正手术的患者中,只有2例后来需要分流。没有产妇发病情况,接受宫内治疗的任何患者均未观察到感染情况。

结论

在孕32周前诊断出的孤立性、进行性、非破坏性脑积水的特定病例可能受益于胎儿神经外科手术。随着诊断准确性的提高,符合该组标准的患者数量已变得非常少。

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