Cavalheiro Sergio, Moron Antonio Fernandes, Hisaba Wagner, Dastoli Patrícia, Silva Nasjala Saba
Section of Pediatric Neurosurgery, Federal University of São Paulo, Rua Botucatu 591/42, 04023-062 São Paulo, Brazil.
Childs Nerv Syst. 2003 Aug;19(7-8):529-36. doi: 10.1007/s00381-003-0770-9. Epub 2003 Aug 8.
Fetal intracranial tumors are rare and their evolution is usually poor. With routine use of antenatal ultrasound imaging, a larger number of such tumors have been diagnosed.
During the period from January 1992 to January 2002, 18 cases diagnosed as intracranial tumors in the fetal stage were treated in the Neurosurgery and Obstetrics Departments of the Federal University of São Paulo and in the Fetal Medicine Service of the Maternity Hospital Santa Joana.
The tumors most frequently found were those of the choroid plexus and teratomas. Out of those 18 cases, 11 patients presented with fetal hydrocephalus, and 5 of them, who were less than 34 weeks old (gestational age), underwent repeated cephalocenteses while awaiting better conditions for delivery. Two fetuses died while in utero before any intervention had taken place and 16 underwent craniotomy after birth. Twelve of those patients are still alive, 9 of whom are considered normal. The 3 others are slightly or moderately retarded.
胎儿颅内肿瘤较为罕见,其病情发展通常较差。随着产前超声成像的常规使用,已诊断出更多此类肿瘤。
在1992年1月至2002年1月期间,圣保罗联邦大学神经外科和妇产科以及圣若阿娜妇产医院胎儿医学科对18例在胎儿期被诊断为颅内肿瘤的病例进行了治疗。
最常发现的肿瘤是脉络丛肿瘤和畸胎瘤。在这18例病例中,11例患者出现胎儿脑积水,其中5例孕周小于34周的患者在等待更好的分娩条件时接受了多次头颅穿刺。2例胎儿在未进行任何干预前于宫内死亡,16例在出生后接受了开颅手术。其中12例患者仍存活,9例被认为正常。另外3例有轻度或中度智力发育迟缓。