Rachitskaya Aleksandra V, Lee Richard K, Dubovy Sander R, Schiff Eugene R
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 900 N.W. 17th Street, Miami, FL 33136, USA.
Eur J Ophthalmol. 2012 Mar-Apr;22(2):284-7. doi: 10.5301/ejo.5000037.
Interferon (IFN) is a mainstay medication used for treatment of chronic hepatitis C, as well as for treatment of certain neoplastic and autoimmune conditions. We present a case of a 50-year-old man who, while on IFN treatment, developed central retinal vein and artery occlusions complicated by the development of neovascular glaucoma secondary to severe retinal ischemia. Interferon retinopathy is associated with ischemic retinal cotton-wool spots. This case illustrates how IFN can lead to severe and sight-threatening retinal ischemia.
Case report.
A 50-year-old man with previously good vision presented with decreased vision in the right eye while being treated with IFN therapy for chronic hepatitis C. He was diagnosed with central retinal vein occlusion and 2 weeks later also developed a central retinal artery occlusion. His course was complicated by the development of neovascular glaucoma. The final visual acuity was ultimately light perception.
Interferon therapy is commonly utilized for chronic hepatitis C, neoplastic conditions, and multiple sclerosis. Clinicians should be aware of the sight-threatening complications of IFN therapy, especially with regard to ocular vaso-occlusive disease and severe retinal ischemia.
干扰素（IFN）是用于治疗慢性丙型肝炎以及某些肿瘤和自身免疫性疾病的主要药物。我们报告一例50岁男性病例，该患者在接受干扰素治疗期间发生了视网膜中央静脉和动脉阻塞，并因严重视网膜缺血继发新生血管性青光眼。干扰素视网膜病变与缺血性视网膜棉绒斑有关。本病例说明了干扰素如何导致严重的、威胁视力的视网膜缺血。
病例报告。
一名既往视力良好的50岁男性在接受干扰素治疗慢性丙型肝炎时出现右眼视力下降。他被诊断为视网膜中央静脉阻塞，2周后又出现了视网膜中央动脉阻塞。他的病程因新生血管性青光眼的发生而复杂化。最终视力仅为光感。
干扰素疗法常用于慢性丙型肝炎、肿瘤疾病和多发性硬化症。临床医生应意识到干扰素治疗的视力威胁性并发症，尤其是眼部血管阻塞性疾病和严重视网膜缺血方面。
