多功能、生物相容性的超分子水凝胶由碱基、氨基酸和糖苷组成。
Multifunctional, biocompatible supramolecular hydrogelators consist only of nucleobase, amino acid, and glycoside.
机构信息
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454, USA.
出版信息
J Am Chem Soc. 2011 Nov 2;133(43):17513-8. doi: 10.1021/ja208456k. Epub 2011 Oct 7.
Abstract
The integration of nucleobase, amino acid, and glycoside into a single molecule results in a novel class of supramolecular hydrogelators, which not only exhibit biocompatibility and biostability but also facilitate the entry of nucleic acids into cytosol and nuclei of cells. This work illustrates a simple way to generate an unprecedented molecular architecture from the basic biological building blocks for the development of sophisticated soft nanomaterials, including supramolecular hydrogels.
摘要
将碱基、氨基酸和糖苷整合到单个分子中会产生一类新型的超分子水凝胶，这类水凝胶不仅具有生物相容性和生物稳定性，还能促进核酸进入细胞的细胞质和细胞核。这项工作展示了一种从基本生物构建块生成前所未有的分子结构的简单方法，可用于开发复杂的软纳米材料，包括超分子水凝胶。
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