• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

色氨酸 - PNA gc 缀合物自组装形成纤维。

Tryptophan-PNA gc Conjugates Self-Assemble to Form Fibers.

机构信息

Dipartimento di Scienze Farmaceutiche, Università Degli Studi di Milano, via Venezian 21, 20133 Milano, Italy.

Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milano, Italy.

出版信息

Bioconjug Chem. 2023 Aug 16;34(8):1429-1438. doi: 10.1021/acs.bioconjchem.3c00200. Epub 2023 Jul 24.

DOI:10.1021/acs.bioconjchem.3c00200
PMID:37486977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10436247/
Abstract

Peptide nucleic acids and their conjugates to peptides can self-assemble and generate complex architectures. In this work, we explored the self-assembly of PNA dimers conjugated to the dipeptide WW. Our studies suggest that the indole ring of tryptophan promotes aggregation of the conjugates. The onset of fluorescence is observed upon self-assembly. The structure of self-assembled WWgc is concentration-dependent, being spherical at low concentrations and fibrous at high concentrations. As suggested by molecular modeling studies, fibers are stabilized by stacking interactions between tryptophans and Watson-Crick hydrogen bonds between nucleobases.

摘要

肽核酸及其与肽的缀合物可以自组装并生成复杂的结构。在这项工作中，我们探索了与二肽 WW 缀合的 PNA 二聚体的自组装。我们的研究表明，色氨酸的吲哚环促进了缀合物的聚集。自组装时观察到荧光的出现。自组装的 WWgc 的结构取决于浓度，在低浓度时呈球形，在高浓度时呈纤维状。分子建模研究表明，纤维通过色氨酸之间的堆积相互作用和碱基之间的 Watson-Crick 氢键稳定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/b3cbccf6c2fe/bc3c00200_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/2c72b1c922c7/bc3c00200_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/4fc1da145ebb/bc3c00200_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/58a6927fefb6/bc3c00200_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/da2b69678df4/bc3c00200_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/fea6182db211/bc3c00200_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/d319ba297275/bc3c00200_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/b3cbccf6c2fe/bc3c00200_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/2c72b1c922c7/bc3c00200_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/4fc1da145ebb/bc3c00200_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/58a6927fefb6/bc3c00200_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/da2b69678df4/bc3c00200_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/fea6182db211/bc3c00200_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/d319ba297275/bc3c00200_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d05a/10436247/b3cbccf6c2fe/bc3c00200_0008.jpg

相似文献

1
Tryptophan-PNA gc Conjugates Self-Assemble to Form Fibers.色氨酸 - PNA gc 缀合物自组装形成纤维。
Bioconjug Chem. 2023 Aug 16;34(8):1429-1438. doi: 10.1021/acs.bioconjchem.3c00200. Epub 2023 Jul 24.
2
Diphenylalanine Motif Drives Self-Assembling in Hybrid PNA-Peptide Conjugates.二苯丙氨酸基序驱动杂合 PNA-肽缀合物的自组装。
Chemistry. 2021 Oct 13;27(57):14307-14316. doi: 10.1002/chem.202102481. Epub 2021 Aug 31.
3
Fluorescence and Morphology of Self-Assembled Nucleobases and Their Diphenylalanine Hybrid Aggregates.自组装核碱基及其与二苯丙氨酸杂化聚集体的荧光和形态。
Chemistry. 2019 Nov 22;25(65):14850-14857. doi: 10.1002/chem.201902709. Epub 2019 Oct 25.
4
Light-emitting self-assembled peptide nucleic acids exhibit both stacking interactions and Watson-Crick base pairing.发光自组装肽核酸同时表现出堆积相互作用和沃森-克里克碱基配对。
Nat Nanotechnol. 2015 Apr;10(4):353-60. doi: 10.1038/nnano.2015.27. Epub 2015 Mar 16.
5
Pyrrolidinyl PNA with α/β-Dipeptide Backbone: From Development to Applications.吡咯烷酮亚甲基（Pyrrolidinyl）肽核酸（PNA）：从研发到应用。
Acc Chem Res. 2015 Jun 16;48(6):1645-56. doi: 10.1021/acs.accounts.5b00080. Epub 2015 May 29.
6
Chiral Fibers Formation Upon Assembly of Tetraphenylalanine Peptide Conjugated to a PNA Dimer.手性纤维的形成：四苯丙氨酸肽与 PNA 二聚体的组装。
Chemistry. 2022 Jul 1;28(37):e202200693. doi: 10.1002/chem.202200693. Epub 2022 May 23.
7
Self-Assembling of Fmoc-GC Peptide Nucleic Acid Dimers into Highly Fluorescent Aggregates.芴甲氧羰基-甘氨酸-胞嘧啶肽核酸二聚体自组装成高荧光聚集体。
Chemistry. 2018 Mar 26;24(18):4729-4735. doi: 10.1002/chem.201800279. Epub 2018 Feb 28.
8
Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network.显示双链-三链网络的部分自互补肽核酸（PNA）寡聚物的晶体结构。
J Am Chem Soc. 2005 Feb 9;127(5):1424-30. doi: 10.1021/ja0458726.
9
Insertion of an internal dipeptide into PNA oligomers: thermal melting studies and further functionalization.将内部二肽插入肽核酸寡聚物：热熔解研究及进一步功能化
Bioorg Med Chem Lett. 2006 Jun 1;16(11):2964-8. doi: 10.1016/j.bmcl.2006.02.071. Epub 2006 Mar 20.
10
Synthesis and RNA-Binding Properties of Extended Nucleobases for Triplex-Forming Peptide Nucleic Acids.扩展型核苷酸碱基的合成及其与三聚体形成肽核酸的 RNA 结合特性。
J Org Chem. 2019 Nov 1;84(21):13276-13298. doi: 10.1021/acs.joc.9b01133. Epub 2019 Oct 2.

引用本文的文献

1
Self-Assembly of Heterochiral and Homochiral Peptides Conjugated to PNA Dimers and Their Integration in Peptide-Based Hydrogels.与肽核酸二聚体共轭的异手性和同手性肽的自组装及其在基于肽的水凝胶中的整合。
Chemistry. 2025 Sep 1;31(49):e02255. doi: 10.1002/chem.202502255. Epub 2025 Aug 13.
2
Nanostructural Modulation of G-Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches.神经退行性变中G-四链体DNA的纳米结构调控：通过实验和计算方法揭示乳清酸的相互作用
J Neurochem. 2025 Jan;169(1):e16296. doi: 10.1111/jnc.16296.
3
Morphology and Applications of Self-Assembled Peptide Nucleic Acids.

本文引用的文献

1
Tryptophan self-assembly yields cytotoxic nanofibers containing amyloid-mimicking and cross-seeding competent conformers.色氨酸自组装产生含有淀粉样蛋白模拟和交叉播种活性构象的细胞毒性纳米纤维。
Nanoscale. 2022 Nov 10;14(43):16270-16285. doi: 10.1039/d2nr03544h.
2
Chiral Fibers Formation Upon Assembly of Tetraphenylalanine Peptide Conjugated to a PNA Dimer.手性纤维的形成：四苯丙氨酸肽与 PNA 二聚体的组装。
Chemistry. 2022 Jul 1;28(37):e202200693. doi: 10.1002/chem.202200693. Epub 2022 May 23.
3
Diphenylalanine Motif Drives Self-Assembling in Hybrid PNA-Peptide Conjugates.
自组装肽核酸的形态和应用。
Int J Mol Sci. 2024 Nov 19;25(22):12435. doi: 10.3390/ijms252212435.
4
BSA Binding and Aggregate Formation of a Synthetic Amino Acid with Potential for Promoting Fibroblast Proliferation: An In Silico, CD Spectroscopic, DLS, and Cellular Study.BSA 结合与潜在促进成纤维细胞增殖的合成氨基酸的聚集形成：一项计算机模拟、圆二色光谱、DLS 和细胞研究。
Biomolecules. 2024 May 14;14(5):579. doi: 10.3390/biom14050579.
二苯丙氨酸基序驱动杂合 PNA-肽缀合物的自组装。
Chemistry. 2021 Oct 13;27(57):14307-14316. doi: 10.1002/chem.202102481. Epub 2021 Aug 31.
4
From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides.从前生物化学到超分子生物医学材料：探索自组装含碱基肽的性质。
Molecules. 2021 Jun 10;26(12):3558. doi: 10.3390/molecules26123558.
5
Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms.天然化合物作为β淀粉样蛋白肽聚集的抑制剂：化学要求和分子机制
Front Neurosci. 2020 Dec 22;14:619667. doi: 10.3389/fnins.2020.619667. eCollection 2020.
6
Discovery of Nucleic Acid Binding Molecules from Combinatorial Biohybrid Nucleobase Peptide Libraries.从组合生物杂交核碱基肽文库中发现核酸结合分子。
J Am Chem Soc. 2020 Nov 18;142(46):19642-19651. doi: 10.1021/jacs.0c08964. Epub 2020 Nov 9.
7
Improving and fine-tuning the properties of peptide-based hydrogels via incorporation of peptide nucleic acids.通过掺入肽核酸改善和微调基于肽的水凝胶的性质。
Nanoscale. 2020 Oct 14;12(38):19905-19917. doi: 10.1039/d0nr03483e. Epub 2020 Sep 28.
8
Self-Assembly of Aromatic Amino Acid Enantiomers into Supramolecular Materials of High Rigidity.芳香族氨基酸对映异构体的自组装成高刚性的超分子材料。
ACS Nano. 2020 Feb 25;14(2):1694-1706. doi: 10.1021/acsnano.9b07307. Epub 2020 Jan 21.
9
Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer.双语言肽核酸：在单一自组装生物聚合物中编码核酸和蛋白质的语言。
J Am Chem Soc. 2019 Dec 4;141(48):19038-19047. doi: 10.1021/jacs.9b09146. Epub 2019 Nov 21.
10
Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation.通过液-液相分离形成氨基酸和肽超分子聚合物的成核和生长。
Angew Chem Int Ed Engl. 2019 Dec 9;58(50):18116-18123. doi: 10.1002/anie.201911782. Epub 2019 Nov 7.