Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, People's Republic of China.
J Nat Prod. 2011 Oct 28;74(10):2128-36. doi: 10.1021/np2004038. Epub 2011 Sep 19.
Seven oleanane-type triterpenoid saponins, named clethroidosides A-G (1-7), an ursane-type triterpenoid saponin, clethroidoside H (8), and six known saponins were isolated from the aerial parts of Lysimachia clethroides. The structures of the saponins were elucidated on the basis of physical data analysis (1D and 2D NMR, HR-ESIMS) and chemical evidence. The cytotoxic activities of compounds 1-14 were evaluated against five human tumor cell lines (HT-29, HePG2, BGC-823, A549, and A375). Compounds 3, 4, 6, and 11-13 exhibited moderate cytotoxic activity, with IC50 values of 0.75-2.62 μM, while compound 5 showed selective cytotoxic activity.
从 Clethra odorata 的地上部分分离得到了 7 个齐墩果烷型三萜皂苷，分别命名为 clethroidosides A-G（1-7），一个乌苏烷型三萜皂苷 clethroidoside H（8），以及 6 个已知的皂苷。基于物理数据分析（1D 和 2D NMR、HR-ESIMS）和化学证据阐明了皂苷的结构。测定了化合物 1-14 对 5 个人类肿瘤细胞系（HT-29、HePG2、BGC-823、A549 和 A375）的细胞毒活性。化合物 3、4、6 和 11-13 表现出中等细胞毒活性，IC50 值为 0.75-2.62 μM，而化合物 5 则表现出选择性细胞毒活性。
