来自变色石竹的三萜皂苷。

Triterpenoid saponins from Dianthus versicolor.

作者信息

Ma Li, Gu Yu-Cheng, Luo Jian-Guang, Wang Jun-Song, Huang Xue-Feng, Kong Ling-Yi

机构信息

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, People's Republic of China.

出版信息

J Nat Prod. 2009 Apr;72(4):640-4. doi: 10.1021/np800589a.

DOI:10.1021/np800589a

PMID:19290648

Abstract

Seven new pentacyclic triterpenoid saponins, named dianversicosides A-G (1-7), together with nine known compounds, were isolated from the aerial parts of Dianthus versicolor. The structures of 1-7 were elucidated on the basis of spectroscopic data and chemical evidence. The absolute configuration of the 3-hydroxyl-3-methylglutaryl (HMG) group in 1-4 was ascertained by chemical analysis combined with a chiral HPLC method. Cytotoxic activities of the isolated compounds were evaluated against a small panel of cancer and other cell lines.

摘要

从变色石竹的地上部分分离得到7个新的五环三萜皂苷，命名为变色石竹皂苷A-G（1-7），以及9个已知化合物。通过光谱数据和化学证据阐明了1-7的结构。采用化学分析与手性高效液相色谱法相结合的方法确定了1-4中3-羟基-3-甲基戊二酰（HMG）基团的绝对构型。对分离得到的化合物针对一小部分癌症和其他细胞系进行了细胞毒性活性评估。