Global Alliance for Improved Nutrition (GAIN), Geneva, Switzerland.
Matern Child Nutr. 2011 Oct;7 Suppl 3(Suppl 3):123-8. doi: 10.1111/j.1740-8709.2011.00355.x.
As a highly bioavailable iron compound, sodium iron (iii) ethylenediaminetetraacetate (NaFeEDTA) has been recommended as a food additive for fortification. The amount of a food additive that can be ingested daily over a lifetime without appreciable health risk is termed the acceptable daily intake (ADI). The ADI for NaFeEDTA is based on body weight. For complementary foods and food supplements for infants and young children in low-income countries, where prevalence of underweight is high yet nutrient needs are also high, it is not clear which doses might be appropriate. The objective is to calculate the dosage of NaFeEDTA for fortifying complementary foods assuming different population prevalences of underweight. Mathematical models were used to simulate the dosage of NaFeEDTA for 6- to 8-month-old infants under different prevalences of underweight ranging from 5% to 40%. In order to keep NaFeEDTA intake below the ADI for ethylenediaminetetraacetate (EDTA) recommended by the Joint Food and Agriculture Organization (FAO)/World Health Organization (WHO) Expert Committee on Food Additives for 95% of 6- to 8-month-old infants, the daily iron dose from NaFeEDTA in fortified complementary foods should be set between 2.2 mg and 1.8 mg in countries with a prevalence of underweight among 6- to 8-month-old infants between 5% and 40%, respectively. If 2 mg of iron is given to all 6- to 8-month-old infants, the percentage exceeding the ADI for EDTA would be <10% for populations with <30% of children who are underweight, which is the case for many countries. In conclusion, 2 mg of iron from NaFeEDTA could be used for fortifying one daily serving of complementary food to ensure EDTA levels are below the ADI for infants 6-8 months of age. An additional source of iron (such as ferrous sulfate) should be included to increase the iron dose to desired fortification levels.
作为一种高生物利用度的铁化合物，乙二胺四乙酸铁钠（NaFeEDTA）已被推荐作为食品强化剂的添加剂。一种食品添加剂，在一生中每天摄入的量不会对健康造成明显风险，这个量被称为每日允许摄入量（ADI）。NaFeEDTA 的 ADI 是基于体重的。对于低收入国家的婴儿和幼儿的补充食品和食品补充剂，由于消瘦的患病率很高，而营养需求也很高，目前尚不清楚哪些剂量可能是合适的。其目的是计算在不同消瘦患病率下强化补充食品的 NaFeEDTA 剂量。数学模型用于模拟不同消瘦患病率（5%至 40%）下 6 至 8 个月大婴儿的 NaFeEDTA 剂量。为了将 NaFeEDTA 的摄入量保持在食品添加剂联合粮食及农业组织（FAO）/世界卫生组织（WHO）专家委员会为 6 至 8 个月大婴儿推荐的乙二胺四乙酸（EDTA）的 ADI 以下，强化补充食品中 NaFeEDTA 的每日铁剂量应设定在 2.2 毫克至 1.8 毫克之间，6 至 8 个月大婴儿消瘦患病率分别在 5%至 40%的国家。如果所有 6 至 8 个月大的婴儿都给予 2 毫克的铁，那么 EDTA 超过 ADI 的百分比对于消瘦儿童比例低于 30%的人群（许多国家都是这种情况）将小于 10%。总之，2 毫克的 NaFeEDTA 铁可用于强化一份每日补充食品，以确保 EDTA 水平低于 6-8 个月龄婴儿的 ADI。应添加另一种铁源（如硫酸亚铁）以增加铁剂量，达到所需的强化水平。
