Richters A, Paller M
J Surg Oncol. 1979;11(1):79-84. doi: 10.1002/jso.2930110114.
The relative frequency of lymphocytes with surface immunoglobulins (sIgM, sIgG, sIgA) was studied in breast-cancer patients' axillary lymph nodes by the immunofluorescence technique. The study encompassed a total of 105 patients, most of whom had infiltrating ductal carcinoma (IDC). The results have indicated a significantly higher (p less than 0.005) average percentage of sIgM positive lymphocytes in lymph nodes in the group of IDC patients with lymph-node metastasis. Short-term followup was available for a limited number of patients, but no conclusions were reached with respect to sIgM positive lymphocytes. It is suggested that evaluation of axillary lymph-node and peripheral blood lymphocyte subpopulations for each cancer patient would provide new information which could aid in determining the extent of the disease process. Moreover, such information may be of assistance in decisions of therapeutic modalities, detection of occult metastasis, and prediction of prognosis.
采用免疫荧光技术研究了乳腺癌患者腋窝淋巴结中具有表面免疫球蛋白（sIgM、sIgG、sIgA）的淋巴细胞的相对频率。该研究共纳入105例患者，其中大多数患有浸润性导管癌（IDC）。结果表明，在有淋巴结转移的IDC患者组中，淋巴结中sIgM阳性淋巴细胞的平均百分比显著更高（p<0.005）。对有限数量的患者进行了短期随访，但未得出关于sIgM阳性淋巴细胞的结论。建议对每位癌症患者的腋窝淋巴结和外周血淋巴细胞亚群进行评估，这将提供有助于确定疾病进程程度的新信息。此外，此类信息可能有助于治疗方式的决策、隐匿性转移的检测和预后的预测。
