Eremin O, Roberts P, Plumb D, Stephens J P
Br J Cancer. 1980 Jan;41(1):62-72. doi: 10.1038/bjc.1980.8.
Axillary lymph nodes draining mammary carcinoma showed an alteration of both micro-architectue and lymphocyte subpopulations. Lymph nodes with a normal or increased T and/or B lymphocyte compartment (assessed by histology) had a low incidence of nodal tumour spread, whilst hypocellularity of the T- or B-lymphocyte-dependent areas was associated with a significant increase in metastatic invasion. Tumour-draining lymph nodes, in particular the more proximal ones, were often enlarged, spherical and tense due to an increased cellular content, predominatly B lymphocytes and their various subsets. The increased number and percentage of B lymphocytes was associated with follicular hyperplasia and prominent germinal centres. Lymph nodes with a prominent paracortex tended to have a higher ratio of T to B lymphocytes than nodes with a hypocellular paracortical area, but in many instances both the T- and B-lymphocyte-dependent areas were increased. There was no correlation between a particular axillary-node lymphocyte subpopulation pattern (assessed by surface markers) and the size, degree of necrosis, inflammatory infiltrate or histologic type of breast carcinoma, or the presence of metastatic node invasion.
引流乳腺癌的腋窝淋巴结显示出微结构和淋巴细胞亚群的改变。T和/或B淋巴细胞区室正常或增加（通过组织学评估）的淋巴结，其淋巴结肿瘤扩散的发生率较低，而T淋巴细胞或B淋巴细胞依赖区的细胞减少与转移浸润的显著增加相关。引流肿瘤的淋巴结，尤其是较近端的淋巴结，由于细胞含量增加，主要是B淋巴细胞及其各种亚群，常常肿大、呈球形且质地紧张。B淋巴细胞数量和百分比的增加与滤泡增生和明显的生发中心相关。副皮质突出的淋巴结往往比副皮质区细胞减少的淋巴结具有更高的T与B淋巴细胞比例，但在许多情况下，T淋巴细胞和B淋巴细胞依赖区均增加。特定腋窝淋巴结淋巴细胞亚群模式（通过表面标志物评估）与乳腺癌的大小、坏死程度、炎性浸润或组织学类型，或转移淋巴结浸润的存在之间没有相关性。
