Kobayashi F, Sagawa N, Okagaki A, Nakamura K, Nonogaki M, Nanbu Y, Ban C, Fujii S, Mori T, Saga T
Department of Gynecology and Obstetrics, Faculty of Medicine, Kyoto University.
Nihon Sanka Fujinka Gakkai Zasshi. 1990 Apr;42(4):327-32.
We examined the CA130 concentration in the amniotic fluid, maternal sera, amnion, chorion, decidua and placenta. CA130 in the maternal sera showed an initial increase during early pregnancy, remained low from the 15th weeks of pregnancy until delivery, and then increased after term delivery (249u/ml, mean, n = 27) or mid-trimester abortions (844u/ml, n = 22). The CA130, concentration in the amniotic fluid was high in the mid-trimester and remarkably low at term. Among the tissues examined, amnion and decidua contained a relatively high concentration of CA130. Immunohistochemical examination also demonstrated abundant CA130 in the cytosol of amnion and decidua tissues. The pattern of changes in CA130 in amniotic fluid was similar to that in the amnion and decidua tissue. The results suggest that the amnion cells are the source of CA130 in the amniotic fluid and that the high concentration of CA130 in maternal serum after delivery originates in decidua tissue affected by the separation of the placenta.
我们检测了羊水、母血、羊膜、绒毛膜、蜕膜和胎盘中CA130的浓度。母血中的CA130在妊娠早期开始时有所升高，从妊娠第15周直至分娩一直保持在较低水平，足月分娩后（平均249u/ml，n = 27）或孕中期流产后（844u/ml，n = 22）则升高。羊水内CA130浓度在孕中期较高，足月时显著降低。在所检测的组织中，羊膜和蜕膜含有相对较高浓度的CA130。免疫组化检查也显示羊膜和蜕膜组织的胞质中有大量CA130。羊水中CA130的变化模式与羊膜和蜕膜组织中的相似。结果表明，羊膜细胞是羊水中CA130的来源，分娩后母血中CA130的高浓度源于受胎盘剥离影响的蜕膜组织。
