Bhansali Anil, Jayaprakash P, Dutta Pinaki, Walia Rama, Ravikumar P
Endocrinology, Postgraduate Institute of Medical Education & Research, Chandigarh, 160012, India.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.03.2009.1677. Epub 2009 Sep 20.
Precocious puberty in a child less than 3 years of age is usually gonadotropin dependent and is often associated with extrasellar central nervous system disorders. The present report describes the case of a 2½-year-old girl who presented with gonadotropin-independent precocious puberty and had a sellar mass. She was referred for neurosurgical intervention to our institute. On investigation, she was found to have primary hypothyroidism of autoimmune aetiology, which is rarely associated with precocious puberty and sellar mass due to thyrotroph hyperplasia. She was successfully treated with levothyroxine, and with this secondary sexual characteristics progressively regressed and the sellar mass disappeared.
3岁以下儿童的性早熟通常依赖促性腺激素，且常与鞍外中枢神经系统疾病相关。本报告描述了一名2岁半女孩的病例，她表现为非促性腺激素依赖性性早熟并伴有鞍区肿物。她被转诊至我院接受神经外科干预。经检查，发现她患有自身免疫性病因的原发性甲状腺功能减退症，这种情况很少与因促甲状腺细胞增生导致的性早熟和鞍区肿物相关。她接受左甲状腺素治疗后获得成功，继发性征逐渐消退，鞍区肿物消失。
