Pringle P J, Stanhope R, Hindmarsh P, Brook C G
Endocrine Unit, Middlesex Hospital, London, UK.
Clin Endocrinol (Oxf). 1988 May;28(5):479-86. doi: 10.1111/j.1365-2265.1988.tb03682.x.
We have studied three patients (1M, 2F), age range 10.9 to 15.5 years, who had abnormal sexual maturation secondary to primary hypothyroidism. The boy had inappropriately large testes for his stage of puberty, the girls had isolated breast development and there was absence of pubertal growth acceleration. FSH, LH, TSH and GH secretion, pituitary imaging and ovarian ultrasound morphology were studied before and during thyroxine treatment. In the hypothyroid state, FSH levels were elevated with abnormal pulsatility and LH:FSH concentrations were reversed.
我们研究了3例患者（1例男性，2例女性），年龄在10.9至15.5岁之间，他们因原发性甲状腺功能减退继发出现性成熟异常。该男孩在青春期阶段睾丸过大，女孩有孤立性乳房发育且缺乏青春期生长加速现象。在甲状腺素治疗前及治疗期间，对促卵泡生成素（FSH）、促黄体生成素（LH）、促甲状腺激素（TSH）和生长激素（GH）分泌、垂体成像及卵巢超声形态进行了研究。在甲状腺功能减退状态下，FSH水平升高且脉冲性异常，LH:FSH浓度倒置。
