Miyata M, Dousei T, Harada T, Aono T, Kitagawa T, Nose O, Kawashima Y
First Department of Surgery, Osaka University Medical School, Japan.
Jpn J Surg. 1990 May;20(3):359-64. doi: 10.1007/BF02470675.
A vertical banded gastroplasty was performed in an adult female patient with Prader-Willi syndrome in an attempt to prevent the metabolic deterioration caused by polyphagia. After her operation, the patient felt satiated with the scheduled amount of food and one month later, her fasting blood sugar concentration (FBS) decreased from 521 to 125 mg/dl, and her urinary sugar excretion (US) from 257 to 9 g/day. Both glucose tolerance and insulin secretion were also improved. However, these parameters subsequently became worse after dietary control was lost since the surgical procedure alone was unable to continue to suppress the insatiable desire to eat food. Both her glucose tolerance and insulin secretion by the 31st postoperative month were better than before the surgery, but worse than at one month after the surgery. At the end of the surgery, but worse than at one month after the surgery. At the end of the 34th postoperative month, even under the temporary administration of 0.625 mg/day of glibenclamide, her FBS was 158 mg/dl and US, 38.1 g/day. Her body weight had also increased to over her preoperative value. Based on these results, we conclude that the effect of gastroplasty to prevent metabolic deterioration in our patient with Prader-Willi syndrome gradually diminishes.
对一名患有普拉德-威利综合征的成年女性患者实施了垂直带状胃成形术，试图预防多食引起的代谢恶化。手术后，患者对规定量的食物感到饱腹，一个月后，她的空腹血糖浓度（FBS）从521降至125mg/dl，尿糖排泄量（US）从257降至9g/天。葡萄糖耐量和胰岛素分泌也得到改善。然而，由于仅手术本身无法持续抑制无法满足的进食欲望，在失去饮食控制后，这些参数随后变差。术后第31个月时，她的葡萄糖耐量和胰岛素分泌均优于手术前，但比术后1个月时差。在术后第34个月末，即使临时服用0.625mg/天的格列本脲，她的FBS仍为158mg/dl，US为38.1g/天。她的体重也增加到超过术前值。基于这些结果，我们得出结论，胃成形术对我们这位普拉德-威利综合征患者预防代谢恶化的效果逐渐减弱。
