在受体异源三聚体同源性三联体难题的起源：不同类型受体中的免疫球蛋白三联体。
On the origin of the triplet puzzle of homologies in receptor heteromers: immunoglobulin triplets in different types of receptors.
机构信息
St. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences, Saint Petersburg, Russia.
出版信息
J Mol Neurosci. 2012 Mar;46(3):616-21. doi: 10.1007/s12031-011-9649-5. Epub 2011 Sep 20.
PMID:21932037
Abstract
Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors which seem to come from immunoglobulin chains and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may "guide-and-clasp" receptor-receptor interactions playing a role, e.g., in neuroinflammation disorders.
摘要
基于我们的理论，我们在 GABAB1 受体和其他几种神经受体中发现了主要的氨基酸残基三联体，这些三联体似乎来自免疫球蛋白链，并且在受体异源二聚体中也表现出同源性。所得结果加强了我们的假设，即这些三联体可能“引导和扣合”受体-受体相互作用，例如在神经炎症紊乱中发挥作用。
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