Pickel K, Solvay M J
Med Microbiol Immunol. 1979 Jan 24;165(4):215-21. doi: 10.1007/BF02152921.
Distinct events in the virus-stimulated T-cell-mediated cytotoxicity (V-CMC) have been investigated: 1.) The induction of V-CMC is possible by immunizing mice with infectious as well as UV-inactivated virus (parainfluenza type 1 strain 6/94), or with virus-infected cells either compatible or imcompatible with the recipient. 2). Recognition of viral antigens by the effector cells occurs independently of the H2 environment: Fractionation of effector cells on columns loaded with virus-infected cells eliminates virus-specific cytotoxic cells. Effector cells and cells on the column need not share H-2 antigens. The findings are discussed with regard to the H2 restriction of the virus induced T-cells mediated cytotoxicity.
已对病毒刺激的T细胞介导的细胞毒性（V-CMC）中的不同事件进行了研究：1.）通过用感染性以及紫外线灭活的病毒（副流感1型6/94株）免疫小鼠，或用与受体相容或不相容的病毒感染细胞免疫小鼠，可诱导V-CMC。2.）效应细胞对病毒抗原的识别独立于H2环境：在装有病毒感染细胞的柱上对效应细胞进行分级分离可消除病毒特异性细胞毒性细胞。效应细胞和柱上的细胞不必共享H-2抗原。针对病毒诱导的T细胞介导的细胞毒性的H2限制对这些发现进行了讨论。
