Graz University of Technology, Institute for Chemistry and Technology of Materials, Stremayrgasse 9/V, 8010 Graz, Austria.
Macromol Rapid Commun. 2011 Nov 15;32(22):1815-9. doi: 10.1002/marc.201100409. Epub 2011 Sep 20.
A 32-membered library of poly(2-oxazoline)-based hydrogels of the composition pEtOx(m) -pPhOx(n) -pPBO(q) (m/n = 150/0, 100/50, 50/100, and 0/150; q = 1.5-30) was prepared from 2-ethyl- (EtOx), 2-phenyl-2-oxazoline (PhOx), and phenylene-1,3-bis-(2-oxazoline) (PBO). The polymerizations were performed from ground monomer mixtures at 140 °C in a single-mode microwave reactor in reaction times as short as 1 h. Purified hydrogels, containing no residual monomers, were obtained in yields of 95% or higher. Acid-mediated hydrolysis rates as well as swelling degrees of the hydrogels were adjustable over a broad range; swelling degrees in water/ethanol/dichloromethane ranged from 0 to 13.8/11.7/20.0. The hydrogels could incorporate organic molecules according to in situ or post-synthetic routines. Post-synthetic routines enabled for the preparation of hydrogels from which the incorporated compounds were only released through diffusion processes if the solvent was changed or through hydrogel degradation if the pH was lowered.
从 2-乙基-（EtOx）、2-苯基-2-恶唑啉（PhOx）和亚苯基-1,3-双-（2-恶唑啉）（PBO）合成了组成 pEtOx(m)-pPhOx(n)-pPBO(q)（m/n=150/0、100/50、50/100 和 0/150；q=1.5-30）的 32 元聚（2-恶唑啉）基水凝胶库。在 140°C 的单模微波反应器中，仅需 1 小时的反应时间，即可从地面单体混合物中进行聚合。纯度为 95%或更高的无残留单体的水凝胶可获得 95%以上的产率。水凝胶的酸介导水解速率和溶胀度可在较宽的范围内调节；在水/乙醇/二氯甲烷中的溶胀度从 0 到 13.8/11.7/20.0。水凝胶可根据原位或后合成方案来包含有机分子。后合成方案可用于制备水凝胶，如果溶剂发生变化，或者如果降低 pH 值，则只能通过扩散过程释放其中包含的化合物；如果水凝胶降解，则只能释放其中包含的化合物。
