Friedrich P
Institute of Enzymology, Hungarian Academy of Sciences, Budapest.
Neuroscience. 1990;35(1):1-7. doi: 10.1016/0306-4522(90)90115-k.
The motility of protein structure, the existence of discrete conformational states, and the multifarious modes of supramolecular protein organization seem to underlie neuronal plasticity. These aspects of protein structure are surveyed from the viewpoint of their potential role in short-term and long-term memory. It is suggested that long-term memory may ensue from the remodelling of synaptic protein assemblies requiring extra copies of pre-existing proteins.
蛋白质结构的动态变化、离散构象状态的存在以及超分子蛋白质组织的多种模式似乎是神经元可塑性的基础。本文从蛋白质结构在短期和长期记忆中的潜在作用的角度对这些方面进行了综述。研究表明，长期记忆可能源于突触蛋白组装的重塑，这需要额外的现有蛋白质拷贝。
