Protein structure: the primary substrate for memory.

The motility of protein structure, the existence of discrete conformational states, and the multifarious modes of supramolecular protein organization seem to underlie neuronal plasticity. These aspects of protein structure are surveyed from the viewpoint of their potential role in short-term and long-term memory. It is suggested that long-term memory may ensue from the remodelling of synaptic protein assemblies requiring extra copies of pre-existing proteins.