蛋白激酶A上的信号汇聚作为学习的分子关联
Signal convergence on protein kinase A as a molecular correlate of learning.
作者信息
Aszódi A, Müller U, Friedrich P, Spatz H C
机构信息
Institute for Enzymology, Hungarian Academy of Sciences, Budapest.
出版信息
Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5832-6. doi: 10.1073/pnas.88.13.5832.
Abstract
The response of a reaction network composed of protein kinase A, calpain, and protein phosphatase to transient cAMP and Ca2+ signals was studied. An essential feature of signal convergence is that the regulatory subunit of cAMP-dissociated protein kinase A undergoes limited proteolysis by the Ca(2+)-activated proteinase calpain. A dynamic model of this system based on kinetic differential equations was built and simulated by computer. The system shows analogies to typical features of associative learning such as acquisition, contiguity detection, extinction, and memory decay, suggesting that these biochemical reactions may be part of the molecular mechanism of learning in Drosophila.
摘要
研究了由蛋白激酶A、钙蛋白酶和蛋白磷酸酶组成的反应网络对瞬时环磷酸腺苷（cAMP）和钙离子（Ca2+）信号的响应。信号汇聚的一个基本特征是，cAMP解离的蛋白激酶A的调节亚基会被Ca(2+)激活的蛋白酶钙蛋白酶进行有限的蛋白水解。基于动力学微分方程构建了该系统的动态模型，并通过计算机进行模拟。该系统显示出与联想学习的典型特征（如习得、接近性检测、消退和记忆衰退）有相似之处，这表明这些生化反应可能是果蝇学习分子机制的一部分。
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