脐带血脂联素与一岁婴儿的生长
Cord blood adiponectin and infant growth at one year.
作者信息
Mazaki-Tovi Shali, Kanety Hannah, Pariente Clara, Hemi Rina, Kuint Jacob, Yinon Yoav, Schiff Eyal, Sivan Eyal
机构信息
Department of Obstetrics and Gynecology, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Israel.
出版信息
J Pediatr Endocrinol Metab. 2011;24(7-8):411-8. doi: 10.1515/jpem.2011.181.
OBJECTIVE
The aim of this study was to determine the association between cord blood adiponectin and leptin and early infant growth at one year in small for gestational age (SGA) and appropriate for gestational age (AGA) infants.
STUDY DESIGN
In this prospective study adiponectin and leptin concentrations were determined in cord blood of (i) AGA newborns (n = 44) and (ii) SGA newborns (n = 24). At one year of age, height and weight were measured. Linear regression analysis was used to determine which factors were associated with anthropometric measurements at the age of one year.
RESULTS
(i) SGA neonates had a significantly lower median cord blood adiponectin and leptin than AGA neonates; (ii) among SGA neonates, cord blood adiponectin concentrations were negatively correlated with body weight at one year, weight gain after one year and with BMI at one year; and (iii) among AGA neonates cord blood adiponectin concentrations were negatively correlated with body weight at one year, weight gain after one year and with BMI at one year.
CONCLUSION
The disparity in cord blood adiponectin and leptin concentrations between SGA and AGA neonates suggests a role for adipokines in fetal growth.
目的
本研究旨在确定小于胎龄儿（SGA）和适于胎龄儿（AGA）脐带血脂联素和瘦素与1岁时婴儿早期生长之间的关联。
研究设计
在这项前瞻性研究中，测定了（i）AGA新生儿（n = 44）和（ii）SGA新生儿（n = 24）脐带血中的脂联素和瘦素浓度。在1岁时测量身高和体重。采用线性回归分析来确定哪些因素与1岁时的人体测量指标相关。
结果
（i）SGA新生儿脐带血脂联素和瘦素的中位数显著低于AGA新生儿；（ii）在SGA新生儿中，脐带血脂联素浓度与1岁时体重、1岁后体重增加以及1岁时BMI呈负相关；（iii）在AGA新生儿中，脐带血脂联素浓度与1岁时体重、1岁后体重增加以及1岁时BMI呈负相关。
结论
SGA和AGA新生儿脐带血脂联素和瘦素浓度的差异表明脂肪因子在胎儿生长中起作用。
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