Al-Daghri Nasser M, Al-Attas Omar S, Alokail Majed S, Alkharfy Khalid M, Hussain Tajamul, Sabico Shaun
Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
J Pediatr Endocrinol Metab. 2011;24(7-8):427-32. doi: 10.1515/jpem.2011.246.
Differences in correlations between leptin, adiponectin and insulin resistance in children exist in different ethnic populations. No such information is available in Arab children. This study aims to fill this gap.
Three hundred and twenty-five prepubertal children were recruited in this cross-sectional study. Body mass index (BMI), waist and hip circumferences and fasting glucose were measured by standard procedures. Serum insulin, leptin and adiponectin were assayed by ELISA.
Leptin and adiponectin levels were significantly correlated with anthropometric parameters, HOMA-IR and insulin in all subjects and with fasting glucose in girls only. Correlations of adiponectin with HOMA-IR and insulin in boys and of leptin with insulin in girls were independent of BMI, waist and hip circumferences.
Gender differences exist in the distribution of adipocytokines in prepubertal children. The associations of adipocytokines with obesity biomarkers in prepubertal children suggest a causal link between childhood obesity and the risk of an early diabetes onset.
不同种族儿童中瘦素、脂联素与胰岛素抵抗之间的相关性存在差异。阿拉伯儿童中尚无此类信息。本研究旨在填补这一空白。
在这项横断面研究中招募了325名青春期前儿童。通过标准程序测量体重指数（BMI）、腰围和臀围以及空腹血糖。采用酶联免疫吸附测定法（ELISA）检测血清胰岛素、瘦素和脂联素。
在所有受试者中，瘦素和脂联素水平与人体测量参数、稳态模型评估胰岛素抵抗（HOMA-IR）及胰岛素显著相关，仅在女孩中与空腹血糖相关。男孩中脂联素与HOMA-IR及胰岛素的相关性以及女孩中瘦素与胰岛素的相关性独立于BMI、腰围和臀围。
青春期前儿童脂肪细胞因子的分布存在性别差异。青春期前儿童脂肪细胞因子与肥胖生物标志物之间的关联表明儿童肥胖与早期糖尿病发病风险之间存在因果联系。
