Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Saudi Diabetes Charity, Riyadh 12721, Saudi Arabia.
Nutrients. 2022 Apr 22;14(9):1759. doi: 10.3390/nu14091759.
This 12-month school-based intervention study investigated the effects of hybrid educational lifestyle modifications on glycemic control among Saudi youth with different glycemic statuses. A total of 2600 Arab adolescents aged 12−18 years were recruited from 60 randomly selected schools. Anthropometrics, blood glucose, and HbA1c were measured pre- and post-intervention. Participants were grouped according to baseline HbA1c into normal, prediabetes, and diabetes groups. All participants received lifestyle education at base line and at every 3-month interval to improve diet and exercise behavior. Diabetic and prediabetic participants received a tailored lifestyle intervention. Post-intervention, 643 participants were analyzed as follows: 20 participants from the diabetes group, 39 from prediabetes, and 584 from the normal group. A modest but significant improvement in the glycemic status of diabetic and prediabetic participants was observed, but not in the normal group. In the diabetes group, 11 (55%) participants achieved normal HbA1c levels, 5 had prediabetes levels, and only 4 remained within diabetes HbA1c levels. In the prediabetes group, 34 (87.2%) participants achieved normal HbA1c levels, while 2 (5.1%) participants remained prediabetic and 3 (7.7%) had diabetes HbA1c levels (p < 0.001). This hybrid lifestyle intervention program modestly reduces the risk of T2DM among youth with elevated HbA1c levels. The challenge of sustaining interest in adopting lifestyle changes for a longer duration should be addressed in further studies in this population.
本为期 12 个月的基于学校的干预研究调查了混合式教育生活方式改变对不同血糖状态的沙特青年血糖控制的影响。从 60 所随机选择的学校中招募了 2600 名 12-18 岁的阿拉伯青少年。在干预前后测量了人体测量学、血糖和 HbA1c。根据基线 HbA1c 将参与者分为正常、糖尿病前期和糖尿病组。所有参与者在基线和每 3 个月间隔接受生活方式教育,以改善饮食和运动行为。糖尿病和糖尿病前期患者接受量身定制的生活方式干预。干预后,对 643 名参与者进行了分析,其中糖尿病组 20 名、糖尿病前期组 39 名、正常组 584 名。观察到糖尿病和糖尿病前期参与者的血糖状况有适度但显著的改善,但正常组没有。在糖尿病组中,11 名(55%)参与者的 HbA1c 水平正常,5 名参与者的血糖水平为糖尿病前期,只有 4 名参与者的 HbA1c 水平仍处于糖尿病水平。在糖尿病前期组中,34 名(87.2%)参与者的 HbA1c 水平正常,2 名(5.1%)参与者仍处于糖尿病前期,3 名(7.7%)参与者的 HbA1c 水平为糖尿病(p<0.001)。这种混合生活方式干预方案适度降低了 HbA1c 升高的青少年患 2 型糖尿病的风险。在该人群的进一步研究中,应解决维持对采用生活方式改变的更长时间的兴趣的挑战。