Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
BMC Pediatr. 2014 Mar 26;14:81. doi: 10.1186/1471-2431-14-81.
There are a limited number of studies regarding the association between abdominal obesity and serum adiponectin complexes (high, medium, and low molecular weight adiponectins) among population-based elementary school children, especially in Japan, where blood collection is not usually performed during annual health examinations of school children. The aim of the present study was to investigate the relationship between abdominal obesity and serum adiponectin complexes among population-based elementary school children in Japan.
Subjects were all the fourth-grade school children (9 or 10 years of age) in the town of Ina during 2005-2008 (N = 1675). The height, weight, percent body fat, and waist circumference (WC) of each subject were measured. Blood samples were drawn from subjects to measure adiponectin isoform values. Childhood abdominal obesity was defined as "a waist-to-height ratio greater than or equal to 0.5" or "a WC greater than or equal to 75 cm". The Wilcoxon rank-sum test and the logistic regression model were used to analyze the association between abdominal obesity and each adiponectin isoform value.
Data from 1654 subjects (846 boys and 808 girls) were analyzed. Adiponectin complexes were lower in the abdominal obesity group than in the non-abdominal obesity group regardless of sex. Abdominal obesity significantly increased the odds ratio (OR) for each adiponectin isoform level less than or equal to the median value in boys; the OR (95% confidence interval [CI]) was 2.50 (1.59-3.92) for high molecular weight adiponectin (HMW-adn), 2.47 (1.57-3.88) for medium molecular weight adiponectin (MMW-adn), and 1.75 (1.13-2.70) for low molecular weight adiponectin (LMW-adn). In girls, the OR (95% CI) was 1.95 (1.18-3.21) for HMW-adn, 1.40 (0.86-2.28) for MMW-adn, and 1.06 (0.65-1.70) for LMW-adn.
Abdominal obesity was associated with lower adiponectin complexes and the influence of abdominal obesity varied by adiponectin isoform. Furthermore, the impact of abdominal obesity was larger in boys than in girls. The present study results suggest that prevention of abdominal obesity could contribute to the prevention of lower adiponectin levels, especially in boys.
在基于人群的小学生中，关于腹部肥胖与血清脂联素复合物（高分子量、中分子量和低分子量脂联素）之间的关联的研究数量有限，尤其是在日本，通常不在儿童年度体检中采集血液样本。本研究的目的是调查日本基于人群的小学生中腹部肥胖与血清脂联素复合物之间的关系。
研究对象为 2005 年至 2008 年期间井内町所有四年级学生（9 或 10 岁）（N=1675）。测量每位受试者的身高、体重、体脂百分比和腰围（WC）。从受试者中抽取血液样本以测量脂联素同工型值。儿童期腹部肥胖定义为“腰高比大于或等于 0.5”或“WC 大于或等于 75cm”。采用 Wilcoxon 秩和检验和逻辑回归模型分析腹部肥胖与各脂联素同工型值之间的关系。
分析了 1654 名受试者（846 名男孩和 808 名女孩）的数据。无论性别如何，腹部肥胖组的脂联素复合物均低于非腹部肥胖组。腹部肥胖显著增加了男孩中低于或等于中位数的每种脂联素同工型水平的比值比（OR）；高分子量脂联素（HMW-adn）、中分子量脂联素（MMW-adn）和低分子量脂联素（LMW-adn）的 OR（95%置信区间[CI]）分别为 2.50（1.59-3.92）、2.47（1.57-3.88）和 1.75（1.13-2.70）。在女孩中，HMW-adn 的 OR（95%CI）为 1.95（1.18-3.21），MMW-adn 为 1.40（0.86-2.28），LMW-adn 为 1.06（0.65-1.70）。
腹部肥胖与较低的脂联素复合物相关，腹部肥胖的影响因脂联素同工型而异。此外，腹部肥胖对男孩的影响大于女孩。本研究结果表明，预防腹部肥胖有助于预防较低的脂联素水平，尤其是在男孩中。
