Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia.
Acta Physiol (Oxf). 2012 Apr;204(4):544-54. doi: 10.1111/j.1748-1716.2011.02363.x. Epub 2011 Oct 31.
To investigate the effect of carbon monoxide (CO) in the inspired air as anticipated during peak hours of traffic in polluted megalopolises on cerebral, respiratory and leg muscle oxygenation during a constant-power test (CPT). In addition, since O(2) breathing is used to hasten elimination of CO from the blood, we examined the effect of breathing O(2) following exposure to CO on cerebral and muscle oxygenation during a subsequent exercise test under CO conditions.
Nine men participated in three trials: (i) 3-h air exposure followed by a control CPT, (ii) 1-h air and 2-h CO (18.9 ppm) exposure succeeded by a CPT under CO conditions (CPT(COA)), and (iii) 2-h CO and 1-h 100% normobaric O(2) exposure followed by a CPT under CO conditions (CPT(COB)). All exercise tests were performed at 85% of peak power output to exhaustion. Oxygenated (Δ[O(2)Hb]), deoxygenated (Δ[HHb]) and total (Δ[tHb]) haemoglobin in cerebral, intercostal and vastus lateralis muscles were monitored with near-infrared spectroscopy throughout the CPTs.
Performance time did not vary between trials. However, the vastus lateralis and intercostal Δ[O(2)Hb] and Δ[tHb] were lower in CPT(COA) than in CPT. During the CPT(COB), the intercostal Δ[O(2) Hb] and Δ[tHb] were higher than in the CPT(COA). There were no differences in cerebral oxygenation between the trials.
Inspiration of 18.9 ppm CO decreases oxygenation in the vastus lateralis and serratus anterior muscles, but does not affect performance. Breathing normobaric O(2) moderates the CO-induced reductions in muscle oxygenation, mainly in the intercostals, but does not affect endurance.
研究在污染大都市交通高峰期间吸入空气中预期的一氧化碳（CO）对恒功率测试（CPT）期间大脑、呼吸和腿部肌肉氧合的影响。此外，由于使用 O₂呼吸来加速 CO 从血液中的清除，我们研究了在 CO 条件下进行后续运动测试前暴露于 CO 后呼吸 O₂对大脑和肌肉氧合的影响。
9 名男性参加了三项试验：（i）3 小时空气暴露后进行对照 CPT，（ii）1 小时空气和 2 小时 CO（18.9 ppm）暴露后在 CO 条件下进行 CPT（CPT（COA）），以及（iii）2 小时 CO 和 1 小时 100%常压 O₂暴露后在 CO 条件下进行 CPT（CPT（COB））。所有运动测试均在 85%的峰值功率输出下进行至力竭。通过近红外光谱在整个 CPT 期间监测大脑、肋间和股外侧肌中的氧合（Δ[O₂Hb]）、去氧（Δ[HHb]）和总（Δ[tHb]）血红蛋白。
试验之间的运动表现时间没有差异。然而，与 CPT 相比，CPT（COA）中的股外侧肌和肋间 Δ[O₂Hb]和 Δ[tHb]较低。在 CPT（COB）期间，肋间 Δ[O₂Hb]和 Δ[tHb]高于 CPT（COA）。三次试验之间大脑氧合没有差异。
吸入 18.9 ppm CO 会降低股外侧肌和前锯肌的氧合，但不影响运动表现。呼吸常压 O₂可减轻 CO 引起的肌肉氧合降低，主要在肋间，但不影响耐力。
