IL28B 基因多态性与埃及队列中丙型肝炎病毒基因型 4 感染的自发清除有关。
Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis C virus genotype 4 infection in an Egyptian cohort.
机构信息
Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
出版信息
J Infect Dis. 2011 Nov;204(9):1391-4. doi: 10.1093/infdis/jir536. Epub 2011 Sep 20.
Abstract
Single-nucleotide polymorphisms (SNPs) around IL28B are associated with spontaneous hepatitis C virus (HCV) clearance of genotypes 1 and 3 in white and African-American populations. This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance). The protective C allele was more common in those with spontaneous clearance (76.3% vs 57.9%; P = .0006). Individuals with clearance were 3.4 (95% confidence interval, 1.8-6.5) times more likely to have C/C genotype. Thus, IL28B plays a role in spontaneous clearance of HCV genotype 4 in North Africa.
摘要
单核苷酸多态性（SNPs）在 IL28B 周围与白人及非裔美国人中 1 型和 3 型丙型肝炎病毒（HCV）的自发清除有关。本研究调查了 IL28B SNP（rs12979860）是否与 162 名埃及人（80 名清除者）中 HCV 主要基因型 4 的自发清除有关。在自发清除者中，保护性 C 等位基因更为常见（76.3% vs 57.9%；P =.0006）。清除者更有可能具有 C/C 基因型（优势比，3.4；95%置信区间，1.8-6.5）。因此，IL28B 在北非 HCV 基因型 4 的自发清除中发挥作用。
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