Gupta Sanjeev K, Sharma Monica, Tyagi Seema, Pati Hara P
Department of Haematology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
Indian J Pathol Microbiol. 2011 Jul-Sep;54(3):609-11. doi: 10.4103/0377-4929.85112.
Apparent hemoglobinopathy acquired after blood transfusion is an uncommon cause of diagnostic dilemma resulting in repeated testing and delay in the diagnosis. Out of the 1530 hemoglobin (Hb)-high-performance liquid chromatography (HPLC) performed at our hospital (May 2009 to April 2010), 3 pediatric cases of thalassemia major were detected having posttransfusion hemoglobinopathy with HbS ranging from 9.9% to 18.5%. In all three cases, there was no variant hemoglobin in earlier documented Hb-HPLC. It is important to be aware of and consider apparent transfusion-induced hemoglobinopathy in patients with unusual percentage of variant hemoglobin to avoid unnecessary treatment and counseling.
输血后获得性血红蛋白病是导致诊断困境、重复检测及诊断延迟的罕见原因。在我院进行的1530次血红蛋白（Hb）高效液相色谱分析（2009年5月至2010年4月）中，检测到3例重型地中海贫血儿科病例出现输血后血红蛋白病，其中镰状血红蛋白（HbS）含量为9.9%至18.5%。在所有3例病例中，既往记录的Hb-HPLC检测均未发现变异血红蛋白。对于变异血红蛋白比例异常的患者，认识并考虑明显的输血诱导血红蛋白病很重要，以避免不必要的治疗和咨询。
