Somasundaram Venkatesan, Purohit Abhishek, Manivannan Prabhu, Saxena Renu
Department of Hematology, All India Institute of Medical Sciences, New Delhi, India.
J Lab Physicians. 2015 Jul-Dec;7(2):128-30. doi: 10.4103/0974-2727.163128.
Transfusion-acquired hemoglobinopathy occurs when a carrier of hemoglobinopathy with no significant abnormalities donates blood, and the blood is transfused to a recipient. This process can lead to spurious results in the recipient without any clinical abnormality or infrequently can result in disastrous situations. The incidental finding of such posttransfusion related abnormal peaks in hemoglobin high-performance liquid chromatography (Hb HPLC) may cause diagnostic dilemmas and result in unnecessary laboratory testing. Here, we report two such cases of transfusion-acquired hemoglobinopathies, which were subsequently resolved by the abnormally low percentage of the Hb variants, transient nature of the peaks, and parental Hb HPLC.
当没有明显异常的血红蛋白病携带者献血，且所献血液被输注给受血者时，就会发生输血获得性血红蛋白病。这个过程可能会在受血者身上导致假结果，而受血者没有任何临床异常，或者极少情况下会导致灾难性后果。在血红蛋白高效液相色谱法（Hb HPLC）中偶然发现这种输血后相关的异常峰，可能会导致诊断困境，并导致不必要的实验室检测。在此，我们报告两例这样的输血获得性血红蛋白病病例，随后通过血红蛋白变异体的异常低百分比、峰的短暂性以及双亲的Hb HPLC得以解决。
