Xi Ren Chong, Biao Wang Shou, Gang Zhang Zhi
QingDao Univercity Medical College, QingDao, China.
Onkologie. 2011;34(8-9):428-32. doi: 10.1159/000331132. Epub 2011 Aug 19.
Survivin and livin are novel members of the inhibitor of apoptosis protein family, which have rarely been studied in human colorectal cancer (CRC). This study aims to examine their expression and association with clinicopathological factors and prognosis in CRC, and evaluate the possibility of their use as biomarkers for CRC.
We investigated the expression of survivin and livin in 61 CRC samples using immunohistochemical staining (Envision) and correlated it with the survival of these patients using log-rank test and correlation analysis.
Among the 61 cases, 60.7 and 54.1% were positive for expression of survivin (p < 0.05) and livin (p < 0.05). No expression of survivin and livin was detected in normal colorectal mucosa. An inverse correlation (r = -0.9916) between the increased survivin and livin levels and overall survival was observed in univariate survival analysis. The expression of both proteins was not correlated with age, gender, degrees of differentiation, and TNM stage (p < 0.05) in malignancies.
High expression of both survivin and livin may influence the prognosis of CRC. This finding opens new perspectives for CRC prognosis because survivin and livin can both be used as biomarkers or potential therapeutic targets.
survivin和livin是凋亡抑制蛋白家族的新成员，在人类结直肠癌（CRC）中鲜有研究。本研究旨在检测它们在CRC中的表达及其与临床病理因素和预后的关系，并评估它们作为CRC生物标志物的可能性。
我们采用免疫组织化学染色（Envision法）检测了61例CRC样本中survivin和livin的表达，并使用对数秩检验和相关性分析将其与这些患者的生存率相关联。
在61例病例中，survivin（p < 0.05）和livin（p < 0.05）表达阳性的分别占60.7%和54.1%。在正常结直肠黏膜中未检测到survivin和livin的表达。单因素生存分析显示，survivin和livin水平升高与总生存期呈负相关（r = -0.9916）。在恶性肿瘤中，这两种蛋白的表达与年龄、性别、分化程度和TNM分期均无相关性（p < 0.05）。
survivin和livin的高表达可能影响CRC的预后。这一发现为CRC的预后开辟了新的视角，因为survivin和livin均可作为生物标志物或潜在的治疗靶点。
