Servicio de Medicina Interna, Hospital Nuestra Señora del Mar, Barcelona, Spain.
Menopause. 2012 Jan;19(1):89-95. doi: 10.1097/gme.0b013e318223bd6b.
The aims of this study were to evaluate the compliance with antiresorptive therapy (ART) and supplements in Spain and to analyze the validity of the different treatment compliance assessment methods.
A cross-sectional study with retrospective data collection was carried out in women starting ART, evaluating indirect objective compliance, self-reported compliance, and the Morisky-Green questionnaire.
A total of 480 women with a mean (SD) age of 65.8 (9.2) years were studied. Of these women, 62.9% received calcium and/or vitamin D supplements in addition to ART. According to the objective compliance method, 76.9% of the women were compliers (≥80%) with bisphosphonates; 69.4%, with selective estrogen receptor modulators; and 61.8%, with supplements (P < 0.01). Using the self-reported compliance, we identified 91% compliers with antiresorptive drugs and 75% with supplements. Using the Morisky-Green test, we classified 60.8% of the women as compliers with antiresorptive drugs and 48.4% with supplements. Combining the objective and self-reported compliance, 29.5% of the women did not adequately comply with ART and 56% with the drug supplements.
With all three compliance measures, supplements were the treatment yielding the lowest percentage of compliers. Bisphosphonates constituted the treatment offering the best objective compliance: 38.2% of the women with drug supplements and between 23.1% and 30.6% of the women with ART failed to exceed the theoretical value of 80% regarded as representing good compliance.
本研究旨在评估西班牙抗吸收治疗（ART）和补充剂的依从性，并分析不同治疗依从性评估方法的有效性。
本研究为回顾性横断面研究，纳入开始 ART 的女性，评估间接客观依从性、自我报告依从性和 Morisky-Green 问卷。
共纳入 480 名年龄（均数±标准差）为 65.8±9.2 岁的女性。其中，62.9%的女性在接受 ART 的同时服用钙和/或维生素 D 补充剂。根据客观依从性方法，76.9%的女性对双膦酸盐的依从性≥80%；69.4%对选择性雌激素受体调节剂的依从性≥80%；61.8%对补充剂的依从性≥80%（P＜0.01）。采用自我报告依从性，我们发现 91%的女性对抗吸收药物的依从性良好，75%的女性对补充剂的依从性良好。采用 Morisky-Green 测试，我们将 60.8%的女性归类为抗吸收药物的依从者，48.4%的女性归类为补充剂的依从者。将客观和自我报告的依从性相结合，29.5%的女性没有充分遵守 ART，56%的女性没有充分遵守药物补充剂。
用所有三种依从性测量方法，补充剂的依从性最低。双膦酸盐是客观依从性最好的治疗方法：38.2%的女性在药物补充剂方面，23.1%至 30.6%的女性在 ART 方面没有超过 80%这一被认为是良好依从性的理论值。
