Department of Public Health, Avicenne Hospital, University of Paris 13, Bobigny, France.
Curr Med Res Opin. 2010 Jul;26(7):1667-74. doi: 10.1185/03007995.2010.483658.
To assess dietary calcium and vitamin D intake and their relationship with prescription medication and nutritional supplement use among postmenopausal women with osteoporosis in France.
Telephone interviews were conducted with 207 postmenopausal women with osteoporosis referred by a random sample of physicians from a French national list. Based on a French food frequency questionnaire, patients reported their daily food intake and frequency as well as their use of prescription medications and nutritional supplements.
Average daily dietary vitamin D intake was only 144.8 IU (SD 84.6, p < 0.01 compared to the recommended 800 IU), with 30% of the sample taking a vitamin D supplement. No participant had more than 500 IU vitamin D daily from food alone and 78% had less than 200 IU per day. A total of 51% of patients took no vitamin D supplements and had less than 5 hours of sun exposure in a week. Patients who were receiving osteoporosis medications and those who were not had comparable vitamin D intake. The average daily dietary calcium intake was 966.4 mg (SD 273.7, p < 0.01 compared to the 800 mg recommended). Calcium supplements were taken by 38% of participants and older patients tended to take more. Limitations of the study include convenience sampling and patient self-report.
Daily vitamin D intake among this sample of postmenopausal osteoporotic women in France was significantly lower than recommended dosages. At least 50% of these patients might benefit by adding vitamin D to their current therapy.
评估法国骨质疏松症绝经后女性的膳食钙和维生素 D 摄入量及其与处方药和营养补充剂使用的关系。
通过电话采访了 207 名由法国国家名单中随机抽取的医生推荐的绝经后骨质疏松症女性。基于法国食物频率问卷,患者报告了他们的日常食物摄入量和频率,以及他们使用处方药和营养补充剂的情况。
平均每日膳食维生素 D 摄入量仅为 144.8IU(SD84.6,与推荐的 800IU 相比,p<0.01),其中 30%的患者服用维生素 D 补充剂。没有参与者仅从食物中获得超过 500IU 的维生素 D,且 78%的人每天摄入的维生素 D 不足 200IU。共有 51%的患者未服用维生素 D 补充剂且每周接受少于 5 小时的阳光照射。服用骨质疏松症药物的患者与未服用药物的患者的维生素 D 摄入量相当。平均每日膳食钙摄入量为 966.4mg(SD273.7,与推荐的 800mg 相比,p<0.01)。38%的参与者服用了钙补充剂,年龄较大的患者往往服用更多。该研究的局限性包括方便抽样和患者自我报告。
法国该样本中绝经后骨质疏松症女性的每日维生素 D 摄入量明显低于推荐剂量。至少 50%的这些患者可能受益于在当前治疗中添加维生素 D。