Asakura Rei, Matsuwaki Takashi, Shim Joo-Hyun, Yamanouchi Keitaro, Nishihara Masugi
Department of Veterinary Physiology, Veterinary Medical Science, University of Tokyo, Tokyo, Japan.
Neuroreport. 2011 Dec 7;22(17):881-6. doi: 10.1097/WNR.0b013e32834bf4ca.
We have previously suggested that progranulin mediates the stimulatory effects of estrogen on adult neurogenesis in the hippocampus. Neurogenesis in mature animals is enhanced by growth factors, environmental enrichment, and voluntary exercise. In this study, we investigated the role of progranulin in voluntary running-induced hippocampal neurogenesis. In the hippocampus of wild-type mice, the pyramidal neurons in the CA1 and CA3 regions and interneurons in the hilus were mainly immunoreactive for progranulin, and wheel running increased progranulin expression in these neurons. Wheel running also increased the number of proliferating cells in the hippocampus in wild-type mice, but not in progranulin-deficient mice. These results suggest that progranulin plays an indispensable role in enhancing the hippocampal neurogenesis induced by voluntary exercise.
我们之前曾提出，颗粒蛋白前体介导雌激素对海马体中成年神经发生的刺激作用。成熟动物体内的神经发生会因生长因子、环境富集和自主运动而增强。在本研究中，我们调查了颗粒蛋白前体在自主跑步诱导的海马体神经发生中的作用。在野生型小鼠的海马体中，CA1和CA3区域的锥体神经元以及齿状回中的中间神经元主要对颗粒蛋白前体呈免疫反应性，并且跑步增加了这些神经元中颗粒蛋白前体的表达。跑步还增加了野生型小鼠海马体中增殖细胞的数量，但在颗粒蛋白前体缺陷型小鼠中则没有增加。这些结果表明，颗粒蛋白前体在增强自主运动诱导的海马体神经发生中起着不可或缺的作用。
