从具有 TRAIL 耐药性克服活性的链霉菌 IFM 11307 中分离得到的新吡喃并萘醌和苯并嗪生物碱。
New pyranonaphthoquinones and a phenazine alkaloid isolated from Streptomyces sp. IFM 11307 with TRAIL resistance-overcoming activity.
机构信息
Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt.
出版信息
J Antibiot (Tokyo). 2011 Nov;64(11):729-34. doi: 10.1038/ja.2011.85. Epub 2011 Sep 21.
Four new pyranonaphthoquinones (1-4) were isolated from the liquid culture of Streptomyces sp. IFM 11307. Additionally, one new phenazine derivative (5), along with the known phenazine-1,6-dicarboxylic acid (6) were identified. The chemical structure of compounds 1-6 was elucidated by 1D and 2D NMR spectroscopy together with CD spectral analysis. Compounds 1-4 significantly overcame tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric adenocarcinoma cell lines.
从链霉菌 IFM 11307 的液体培养物中分离得到了四个新的吡喃并萘醌（1-4）。此外，还鉴定出一个新的吩嗪衍生物（5）以及已知的吩嗪-1,6-二羧酸（6）。通过 1D 和 2D NMR 光谱以及 CD 光谱分析阐明了化合物 1-6 的化学结构。化合物 1-4 显著克服了人胃腺癌细胞系中肿瘤坏死因子相关凋亡诱导配体的耐药性。
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