Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
J Antibiot (Tokyo). 2011 Mar;64(3):271-5. doi: 10.1038/ja.2010.172. Epub 2011 Feb 9.
Three new glycosylated phenazine derivatives, named izuminosides A-C (1-3) have been isolated from the ethyl acetate extract of Streptomyces sp. IFM 11260. The structures of the new compounds were determined on the basis of their spectral data. Compounds 1-3 were evaluated for their activity in overcoming tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance in human gastric adenocarcinoma cells. Compounds 2 (10 μM) and 3 (60 μM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistance AGS cells.
从链霉菌 IFM 11260 的乙酸乙酯提取物中分离得到三个新的糖基吩嗪衍生物，命名为 izuminosides A-C（1-3）。根据光谱数据确定了新化合物的结构。评估了化合物 1-3 在克服人胃腺癌细胞中肿瘤坏死因子相关凋亡诱导配体（TRAIL）耐药性方面的活性。化合物 2（10 μM）和 3（60 μM）与 TRAIL 联合使用对 TRAIL 耐药性 AGS 细胞具有协同作用。
