Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, Japan.
J Nat Prod. 2010 Dec 27;73(12):1999-2002. doi: 10.1021/np100400t. Epub 2010 Nov 23.
Three new phenazine derivatives, named izumiphenazines A-C (1-3), and the known phenazine-1,6-dicarboxylic acid (4) were isolated from Streptomyces sp. IFM 11204. The structures of the isolated compounds were elucidated by means of spectroscopic methods including UV, IR, HRESIMS, and 1D and 2D NMR. Compounds 1-3 were evaluated for their activity in overcoming TRAIL (TNF-related apoptosis-inducing ligand) resistance in human gastric adenocarcinoma cells. Compounds 2 (30 μM) and 3 (20 μM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistant AGS cells.
从链霉菌 sp. IFM 11204 中分离得到三个新的吩嗪衍生物，命名为 izumiphenazines A-C（1-3）和已知的吩嗪-1,6-二羧酸（4）。通过光谱方法包括 UV、IR、HRESIMS 以及 1D 和 2D NMR，阐明了分离化合物的结构。评估了化合物 1-3 在克服人胃腺癌细胞中 TRAIL（TNF 相关凋亡诱导配体）耐药性方面的活性。化合物 2（30 μM）和 3（20 μM）与 TRAIL 联合使用在增敏 TRAIL 耐药 AGS 细胞方面表现出协同活性。
