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用于心肌再生的干细胞。

Stem cells for myocardial regeneration.

机构信息

Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA.

出版信息

Clin Pharmacol Ther. 2011 Oct;90(4):499-501. doi: 10.1038/clpt.2011.196. Epub 2011 Aug 10.

DOI:10.1038/clpt.2011.196
PMID:21934722
Abstract

The field of cardiovascular regenerative medicine has made significant strides over the past decade. Clinical trials have demonstrated benefit in acute myocardial infarction (AMI) and chronic heart failure (CHF). As the field has matured, it has defined novel biology and invented an array of therapeutic strategies that are currently under development. In this brief review, we attempt to conceptualize the knowledge to date as well as examine how this knowledge has been translated to various therapeutic strategies.

摘要

在过去的十年中,心血管再生医学领域取得了重大进展。临床试验已经证明了其在急性心肌梗死(AMI)和慢性心力衰竭(CHF)中的益处。随着该领域的成熟,它已经定义了新的生物学,并发明了一系列目前正在开发的治疗策略。在这篇简短的综述中,我们试图将迄今为止的知识概念化,并研究这些知识是如何转化为各种治疗策略的。

相似文献

1
Stem cells for myocardial regeneration.用于心肌再生的干细胞。
Clin Pharmacol Ther. 2011 Oct;90(4):499-501. doi: 10.1038/clpt.2011.196. Epub 2011 Aug 10.
2
Cell delivery in cardiac regenerative therapy.细胞在心脏再生治疗中的递送。
Ageing Res Rev. 2012 Jan;11(1):32-40. doi: 10.1016/j.arr.2011.06.002. Epub 2011 Jun 28.
3
Cell-based cardiovascular repair and regeneration in acute myocardial infarction and chronic ischemic cardiomyopathy-current status and future developments.急性心肌梗死和慢性缺血性心肌病中基于细胞的心血管修复与再生——现状与未来发展
Int J Dev Biol. 2011;55(4-5):407-17. doi: 10.1387/ijdb.103219ct.
4
[Cardiovascular regenerative medicine at the crossroads. Clinical trials of cellular therapy must now be based on reliable experimental data from animals with characteristics similar to human's].心血管再生医学处于十字路口。细胞治疗的临床试验现在必须基于来自具有与人类相似特征的动物的可靠实验数据。
Rev Esp Cardiol. 2006 Nov;59(11):1175-89.
5
The future of cell therapy for acute myocardial infarction.急性心肌梗死细胞治疗的未来。
Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S129-32. doi: 10.1038/ncpcardio0432.
6
Myocardial cell therapy at the crossroads.心肌细胞治疗处于十字路口。
Nat Clin Pract Cardiovasc Med. 2007 Jan;4(1):1. doi: 10.1038/ncpcardio0743.
7
Stem cell therapy after myocardial infarction: ready for clinical application?心肌梗死后的干细胞治疗:准备好用于临床应用了吗?
Curr Opin Mol Ther. 2006 Oct;8(5):396-414.
8
Potential use of endothelial progenitor cells for regeneration of the vasculature.内皮祖细胞在血管再生中的潜在应用。
Ther Adv Cardiovasc Dis. 2009 Feb;3(1):17-27. doi: 10.1177/1753944708097728.
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Stem cell transplantation in myocardial infarction.心肌梗死中的干细胞移植。
Rev Cardiovasc Med. 2004 Spring;5(2):82-98.
10
Systemic stem cell improvement in cardiac function after ischaemic injury: leaping forward slowly.缺血性损伤后心脏功能的系统性干细胞改善:缓慢前行,大步跨越。
Clin Exp Pharmacol Physiol. 2008 Feb;35(2):105-6. doi: 10.1111/j.1440-1681.2007.04842.x.

引用本文的文献

1
Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation.心肌修复与心肌再生:机制与治疗调节。
Methodist Debakey Cardiovasc J. 2024 Aug 20;20(4):31-41. doi: 10.14797/mdcvj.1400. eCollection 2024.
2
Efficacy and Safety of Stem Cell Therapy in Advanced Heart Failure Patients: A Systematic Review with a Meta-analysis of Recent Trials Between 2017 and 2019.干细胞疗法在晚期心力衰竭患者中的疗效与安全性:一项对2017年至2019年间近期试验的系统评价与荟萃分析
Cureus. 2019 Sep 6;11(9):e5585. doi: 10.7759/cureus.5585.
3
Comparison of Cardiomyocyte Differentiation Potential Between Type 1 Diabetic Donor- and Nondiabetic Donor-Derived Induced Pluripotent Stem Cells.
1型糖尿病供体和非糖尿病供体来源的诱导多能干细胞之间心肌细胞分化潜能的比较。
Cell Transplant. 2015;24(12):2491-504. doi: 10.3727/096368914X685762. Epub 2015 Jan 5.
4
Regenerative medicine: transforming the drug discovery and development paradigm.再生医学:转变药物发现与开发模式。
Cold Spring Harb Perspect Med. 2014 Aug 1;4(8):a014084. doi: 10.1101/cshperspect.a014084.
5
Getting at the heart of the issue: advanced imaging and stem cell-based therapy offer a novel approach to cardiac resynchronization.直击问题核心:先进成像技术和基于干细胞的疗法为心脏再同步化提供了一种新方法。
J Physiol. 2013 Nov 1;591(21):5271-2. doi: 10.1113/jphysiol.2013.263210.
6
Stem cell therapy for heart disease.干细胞治疗心脏病。
J Gen Intern Med. 2013 Oct;28(10):1353-63. doi: 10.1007/s11606-013-2508-z. Epub 2013 Jun 15.
7
Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction.诱导多能干细胞干预挽救心室壁运动差异,实现梗死后的生物学心脏再同步。
J Physiol. 2013 Sep 1;591(17):4335-49. doi: 10.1113/jphysiol.2013.252288. Epub 2013 Apr 8.
8
MRI reporter genes: applications for imaging of cell survival, proliferation, migration and differentiation.MRI 报告基因:用于细胞存活、增殖、迁移和分化成像的应用。
NMR Biomed. 2013 Jul;26(7):872-84. doi: 10.1002/nbm.2869. Epub 2012 Dec 6.
9
Pretreatment of therapeutic cells with poly(ADP-ribose) polymerase inhibitor enhances their efficacy in an in vitro model of cell-based therapy in myocardial infarct.用聚(ADP-核糖)聚合酶抑制剂预处理治疗细胞可增强其在心肌梗死细胞治疗体外模型中的疗效。
Int J Mol Med. 2013 Jan;31(1):26-32. doi: 10.3892/ijmm.2012.1186. Epub 2012 Nov 16.