Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, 1100 Fairview Ave., N M4-B402, Seattle, WA 98109, USA.
Food Funct. 2011 Oct;2(10):579-87. doi: 10.1039/c1fo10114e. Epub 2011 Sep 21.
Isothiocyanates (ITC), derived from glucosinolates, are thought to be responsible for the chemoprotective actions conferred by higher cruciferous vegetable intake. Evidence suggests that isothiocyanates exert their effects through a variety of distinct but interconnected signaling pathways important for inhibiting carcinogenesis, including those involved in detoxification, inflammation, apoptosis, and cell cycle and epigenetic regulation, among others. This article provides an update on the latest research on isothiocyanates and these mechanisms, and points out remaining gaps in our understanding of these events. Given the variety of ITC produced from glucosinolates, and the diverse pathways on which these compounds act, a systems biology approach, in vivo, may help to better characterize their integrated role in cancer prevention. In addition, the effects of dose, duration of exposure, and specificity of different ITC should be considered.
异硫氰酸酯（ITC）来源于硫代葡萄糖苷，被认为是十字花科蔬菜摄入带来的化学预防作用的原因。有证据表明，异硫氰酸酯通过多种不同但相互关联的信号通路发挥作用，这些通路对抑制癌症发生很重要，包括解毒、炎症、细胞凋亡、细胞周期和表观遗传调控等。本文提供了关于异硫氰酸酯及其机制的最新研究的更新，并指出了我们对这些事件理解中仍然存在的差距。鉴于从硫代葡萄糖苷中产生的异硫氰酸酯的多样性，以及这些化合物作用的不同途径，体内的系统生物学方法可能有助于更好地描述它们在癌症预防中的综合作用。此外，还应考虑不同 ITC 的剂量、暴露持续时间和特异性的影响。
