Department of Gastroenterology, Maimonides Medical Center, Brooklyn, NY 11201, USA.
Curr Osteoporos Rep. 2011 Dec;9(4):251-7. doi: 10.1007/s11914-011-0077-9.
Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.
骨质疏松症是炎症性肠病（IBD）患者发病率的主要原因。骨质流失是一个早期的全身过程，甚至在临床疾病表现之前就已经发生。骨病归因于维生素 D 缺乏、类固醇使用和/或全身炎症。在这篇综述中，我们讨论了炎症细胞因子和其他介质介导的骨质流失的分子途径。进一步的研究有望阐明 IBD 中炎症引起的骨质流失的机制，并指导有效的治疗方式。
