Fred Hutchinson Cancer Research Center, 1000 Fairview Ave N M3-A410, Seattle, WA 98109, USA.
Breast Cancer Res Treat. 2012 Jan;131(2):637-43. doi: 10.1007/s10549-011-1770-1. Epub 2011 Sep 21.
The 2008 Physical Activity (PA) Guidelines recommend engaging in at least 2.5 h (10 MET-hours/week) of moderate intensity PA per week (defined as 4 METs) to reduce risk of morbidity and mortality. This analysis was conducted to investigate whether this recommendation can be extended to breast cancer survivors. Data from four studies of breast cancer survivors measuring recreational PA from semi-quantitative questionnaires a median of 23 months post-diagnosis (interquartile range 18-32 months) were pooled in the After Breast Cancer Pooling Project (n = 13,302). Delayed entry Cox proportional hazards models were applied in data analysis with adjustment for age, post-diagnosis body mass index, race/ethnicity, menopausal status, TNM stage, cancer treatment, and smoking history. Engaging in at least 10 MET-hours/week of PA was associated with a 27% reduction in all-cause mortality (n = 1,468 events, Hazard Ratio (HR) = 0.73, 95% CI, 0.66-0.82) and a 25% reduction in breast cancer mortality (n = 971 events, HR = 0.75, 95% CI 0.65-0.85) compared with women who did not meet the PA Guidelines (<10 MET-hours/week). Risk of breast cancer recurrence (n = 1,421 events) was not associated with meeting the PA Guidelines (HR = 0.96, 95% CI, 0.86-1.06). These data suggest that adhering to the PA guidelines may be an important intervention target for reducing mortality among breast cancer survivors.
2008 年体力活动（PA）指南建议每周至少进行 2.5 小时（10 个代谢当量小时/周）的中等强度 PA（定义为 4 METs），以降低发病率和死亡率。本分析旨在探讨这一建议是否可以扩展到乳腺癌幸存者。从四项乳腺癌幸存者研究中收集了数据，这些研究使用半定量问卷测量了发病后中位数为 23 个月（四分位距 18-32 个月）的休闲性 PA（n=13302）。在乳腺癌后汇总项目（After Breast Cancer Pooling Project，ABCP）中，应用延迟进入 Cox 比例风险模型进行数据分析，并调整年龄、发病后体重指数、种族/民族、绝经状态、TNM 分期、癌症治疗和吸烟史。每周至少进行 10 个代谢当量小时的 PA 与全因死亡率降低 27%相关（n=1468 例事件，风险比（Hazard Ratio，HR）=0.73，95%置信区间，0.66-0.82），乳腺癌死亡率降低 25%相关（n=971 例事件，HR=0.75，95%置信区间 0.65-0.85），与未达到 PA 指南（<10 个代谢当量小时/周）的女性相比。与达到 PA 指南相比，乳腺癌复发风险（n=1421 例事件）与达到 PA 指南无关（HR=0.96，95%置信区间，0.86-1.06）。这些数据表明，坚持 PA 指南可能是降低乳腺癌幸存者死亡率的一个重要干预目标。
