Interdisciplinary Graduate School of Science and Technology, Shinshu University, Minamiminowa-mura 8304, Kamiina-gun, Nagano 399-4598, Japan.
J Agric Food Chem. 2011 Oct 26;59(20):11287-93. doi: 10.1021/jf2029225. Epub 2011 Oct 3.
The immunomodulatory effects of a hot water extract from matured fruit of the date palm tree (Phoenix dactylifera L.) were investigated in comparison to those of prune and fig fruit in mice. The number of spleen IFN-γ(+)CD4(+), IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells was highest in mice given the date extract-added diet. Polyphenols identified in the date extract, such as chlorogenic acid, caffeic acid, pelargonin and ferulic acid, stimulated IFN-γ mRNA expression significantly in mouse Peyer's patch cell cultures. Chlorogenic acid and caffeic acid also increased the number of IFN-γ(+)CD4(+) cells significantly, while some polyphenols increased the number of IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. On the other hand, a 70% ethanol-insoluble date extract treated with trypsin increased the number of IFN-γ(+)CD49b(+) and IL-12(+)CD11b(+) cells significantly. These results indicate that some polyphenols and polysaccharides present in date fruit stimulate the cellular immune system in mice.
研究了成熟的椰枣果实（Phoenix dactylifera L.）热水提取物对小鼠的免疫调节作用，并与李子和无花果果实进行了比较。给予添加枣提取物的饮食的小鼠脾脏中 IFN-γ（+）CD4（+）、IFN-γ（+）CD49b（+）和 IL-12（+）CD11b（+）细胞的数量最高。在枣提取物中鉴定的多酚，如绿原酸、咖啡酸、pelargonin 和阿魏酸，在小鼠派伊尔氏斑细胞培养物中显著刺激 IFN-γ mRNA 表达。绿原酸和咖啡酸也显著增加 IFN-γ（+）CD4（+）细胞的数量，而一些多酚则显著增加 IFN-γ（+）CD49b（+）和 IL-12（+）CD11b（+）细胞的数量。另一方面，用胰蛋白酶处理的 70%乙醇不溶性枣提取物显著增加了 IFN-γ（+）CD49b（+）和 IL-12（+）CD11b（+）细胞的数量。这些结果表明，椰枣果实中存在的一些多酚和多糖可刺激小鼠的细胞免疫系统。
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