Muangsanguan Anurak, Ruksiriwanich Warintorn, Linsaenkart Pichchapa, Jantrawut Pensak, Rachtanapun Pornchai, Jantanasakulwong Kittisak, Sommano Sarana Rose, Sringarm Korawan, Arjin Chaiwat, Sainakham Mathukorn, Castagnini Juan M
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Cluster of Valorization and Bio-Green Transformation for Translation Research Innovation of Raw Materials and Products, Chiang Mai University, Chiang Mai 50200, Thailand.
Plants (Basel). 2024 Oct 6;13(19):2802. doi: 10.3390/plants13192802.
Androgenetic alopecia (AGA) is a genetic condition characterized by an excessive response to androgens, leading to hairline regression in men and hair thinning at the vertex in women, which can negatively impact self-esteem. Conventional synthetic treatments for AGA are often limited by their side effects. In contrast, Thai medicinal plants offer a promising alternative with fewer adverse effects. This study investigates the synergistic phytochemical and pharmacological effects of a novel Hair Rise microemulsion, formulated with bioactive extracts from rice bran (), shallot bulb (), licorice root (), and corn kernels (), for the treatment of hair loss. The microemulsion, in concentrations of 50%, 75%, and 100% (/), significantly enhanced the proliferation of human hair follicle dermal papilla cells (HFDPCs) compared to minoxidil. Additionally, it upregulated critical hair growth signaling pathways, including Wnt/β-catenin (), Sonic Hedgehog (, , ), and vascular endothelial growth factor (), surpassing standard controls such as minoxidil and purmorphamine. The microemulsion also demonstrated potent anti-inflammatory and antioxidant properties by reducing nitric oxide production and oxidative stress, factors that contribute to inflammation and follicular damage in AGA. Furthermore, Hair Rise inhibited 5-reductase (types 1-3), a key enzyme involved in androgen metabolism, in both human prostate cancer cells (DU-145) and HFDPCs. These findings suggest that Hair Rise microemulsion presents a promising natural therapy for promoting hair growth and reducing hair loss via multiple synergistic mechanisms, offering a potent, plant-based alternative to synthetic treatments.
雄激素性脱发（AGA）是一种遗传性疾病，其特征是对雄激素过度反应，导致男性发际线后移和女性头顶头发变薄，这会对自尊产生负面影响。AGA的传统合成治疗方法往往受到其副作用的限制。相比之下，泰国药用植物提供了一种副作用较少的有前景的替代方法。本研究调查了一种新型生发微乳剂的协同植物化学和药理作用，该微乳剂由米糠、葱头、甘草根和玉米粒的生物活性提取物配制而成，用于治疗脱发。与米诺地尔相比，浓度为50%、75%和100%（/）的微乳剂显著增强了人毛囊真皮乳头细胞（HFDPCs）的增殖。此外，它上调了关键的毛发生长信号通路，包括Wnt/β-连环蛋白、音猬因子和血管内皮生长因子，超过了米诺地尔和嘌呤吗啡等标准对照。该微乳剂还通过减少一氧化氮的产生和氧化应激表现出强大的抗炎和抗氧化特性，这些因素会导致AGA中的炎症和毛囊损伤。此外，生发微乳剂在人前列腺癌细胞（DU-145）和HFDPCs中均抑制了5-还原酶（1-3型），这是一种参与雄激素代谢的关键酶。这些发现表明，生发微乳剂通过多种协同机制为促进头发生长和减少脱发提供了一种有前景的天然疗法，为合成治疗提供了一种有效的基于植物的替代方法。
