Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
The organization and function of eukaryotic cells rely on the action of many different molecular motor proteins. Cytoplasmic dynein drives the movement of a wide range of cargoes towards the minus ends of microtubules, and these events are needed, not just at the single-cell level, but are vital for correct development. In the present paper, I review recent progress on understanding dynein's mechanochemistry, how it is regulated and how it binds to such a plethora of cargoes. The importance of a number of accessory factors in these processes is discussed.
真核细胞的组织和功能依赖于许多不同的分子马达蛋白的作用。细胞质动力蛋白驱动着广泛的货物向微管的负端移动，这些事件不仅在单细胞水平上是必需的，而且对正确的发育也是至关重要的。在本文中，我回顾了近年来在理解动力蛋白的机械化学、它是如何被调节以及它如何与如此多的货物结合方面的进展。讨论了这些过程中许多辅助因子的重要性。
