异质细菌持久菌及其消除工程方法。
Heterogeneous bacterial persisters and engineering approaches to eliminate them.
机构信息
Howard Hughes Medical Institute, Department of Biomedical Engineering and Center for BioDynamics, Boston University, Boston, MA 02215, USA.
出版信息
Curr Opin Microbiol. 2011 Oct;14(5):593-8. doi: 10.1016/j.mib.2011.09.002. Epub 2011 Sep 19.
Abstract
Bacterial persistence is a state in which a subpopulation of cells (persisters) survives antibiotic treatment, and has been implicated in the tolerance of clinical infections and the recalcitrance of biofilms. There has been a renewed interest in the role of bacterial persisters in treatment failure in light of a wealth of recent findings. Here we review recent laboratory studies of bacterial persistence. Further, we pose the hypothesis that each bacterial population may contain a diverse collection of persisters and discuss engineering strategies for persister eradication.
摘要
细菌持续存在是一种亚群细胞（持续存在者）在抗生素治疗后存活的状态，它与临床感染的耐受性和生物膜的顽固性有关。最近的大量发现再次引起了人们对细菌持续存在者在治疗失败中的作用的兴趣。在这里，我们回顾了最近关于细菌持续存在的实验室研究。此外，我们提出了一个假设，即每个细菌群体可能都包含一系列不同的持续存在者，并讨论了用于消除持续存在者的工程策略。
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