Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland.
J Hum Hypertens. 2012 Nov;26(11):677-83. doi: 10.1038/jhh.2011.85. Epub 2011 Sep 22.
Serum uric acid (SUA) concentration is independently associated with blood pressure (BP) in adults. We examined this association in young adults at an age where anti-hypertension treatment, other potential confounding factors and co-morbidity are unlikely to occur. We assessed BP, anthropometric variables including weight, height, waist circumference (WC), body fat percent (using bioimpedance), lifestyle behaviors, SUA and blood lipids in 549 participants aged 19-20 years from a population-based cohort study (Seychelles Child Development Study). Mean (s.d.) SUA was higher in males than females, 0.33 (0.08) and 0.24 (0.07) mmol l(-1), respectively. Body mass index (BMI) was higher in females than males but BP was markedly higher in males than in females. SUA was associated with both systolic and diastolic BP. However, the magnitude of the linear regression coefficients relating BP and SUA decreased by up to 50% upon adjustment for BMI, WC or body fat percent. The association between SUA and BP was not altered upon further adjustment for alcohol intake, smoking, triglycerides or renal function. In fully adjusted models, SUA remained associated with BP (P<0.05) in females. In conclusion, adiposity substantially decreased the association between SUA and BP in young adults, and BP was independently associated with SUA in females. These findings suggest a role of adiposity in the link between hyperuricemia and hypertension.
血清尿酸（SUA）浓度与成年人的血压（BP）独立相关。我们在年轻人中检查了这种关联，因为在这个年龄段不太可能发生抗高血压治疗、其他潜在的混杂因素和合并症。我们评估了血压、人体测量学变量，包括体重、身高、腰围（WC）、体脂肪百分比（使用生物电阻抗法）、生活方式行为、SUA 和血脂，在一个基于人群的队列研究（塞舌尔儿童发展研究）中，549 名年龄在 19-20 岁的参与者中进行了评估。男性的平均（标准差）SUA 高于女性，分别为 0.33（0.08）和 0.24（0.07）mmol/l（-1）。女性的 BMI 高于男性，但男性的血压明显高于女性。SUA 与收缩压和舒张压均有关。然而，在调整 BMI、WC 或体脂肪百分比后，BP 和 SUA 之间的线性回归系数的幅度降低了多达 50%。进一步调整饮酒、吸烟、甘油三酯或肾功能后，SUA 与 BP 之间的关联没有改变。在完全调整的模型中，SUA 与女性的 BP 仍然相关（P<0.05）。总之，肥胖症显著降低了 SUA 与 BP 之间的关联，而 BP 与 SUA 在女性中独立相关。这些发现表明肥胖在高尿酸血症和高血压之间的联系中起作用。
