Department of Gastroenterology, Rabin Medical Center, Beilinson Campus and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
J Crohns Colitis. 2011 Oct;5(5):461-4. doi: 10.1016/j.crohns.2011.04.006. Epub 2011 May 10.
Adenocarcinomas of the large and small bowel, as well as intestinal carcinoid tumors have been reported at increased rates in Crohn's disease. We herein report a rare case of concurrent adenocarcinoma and carcinoid tumor of the small bowel presenting as intestinal obstruction and found incidentally at laparotomy in a 55 year old male with longstanding ileal Crohn's disease. We performed a Medline Pubmed search for cases of synchronous or composite adenocarcinoma and carcinoid tumor in the setting of Crohn's disease and identified four similar cases. Concurrent adenocarcinoma and carcinoid tumor occurred both in newly diagnosed and longstanding Crohn's disease, most commonly involved the terminal ileum and presented with symptoms mimicking Crohn's disease. Diagnosis was made incidentally at laparotomy in all cases. Lymph node involvement was variable. Clinicians should be aware of this rare entity for expeditious surgical intervention.
已有报道称,在克罗恩病患者中,大肠和小肠的腺癌以及肠类癌肿瘤的发病率增高。本文报告一例罕见的同时发生于小肠的腺癌和类癌肿瘤的病例,该病例以肠梗阻为表现,并在一例患有长期回肠克罗恩病的 55 岁男性患者的剖腹手术中偶然发现。我们对克罗恩病背景下同时发生或复合性腺癌和类癌肿瘤的病例进行了 Medline Pubmed 检索,共确定了 4 例相似病例。同时发生的腺癌和类癌肿瘤既可见于新诊断的克罗恩病,也可见于长期的克罗恩病,最常累及末端回肠,并以类似于克罗恩病的症状表现。所有病例均在剖腹手术中偶然发现诊断。淋巴结受累情况不一。临床医生应意识到这种罕见的疾病,以便及时进行手术干预。