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肝移植后尽管进行了最大程度的免疫抑制仍发生暴发性溃疡性结肠炎:病例报告及文献复习。

Fulminant ulcerative colitis despite maximal immunosuppression following liver transplantation: a case report and literature review.

机构信息

Gastroenterology Unit, Southern District Health Board, Dunedin, New Zealand.

出版信息

J Crohns Colitis. 2011 Oct;5(5):465-8. doi: 10.1016/j.crohns.2011.04.011. Epub 2011 May 18.

Abstract

Inflammatory Bowel Disease (IBD) is thought to be the result of an overly aggressive immune response to ubiquitous antigens. Immuno -modulation and -suppression is therefore currently the treatment of choice. It was long anticipated that the course of pre-existing IBD should improve after orthotopic liver transplantation (OLT) due to increased immunosuppression. We report the case of a patient who developed acute fulminant colitis despite triple immunosuppression and mesalazine and review the relevant literature.

摘要

炎症性肠病(IBD)被认为是对普遍存在的抗原过度活跃的免疫反应的结果。因此,免疫调节和抑制目前是首选的治疗方法。人们长期以来一直预期,由于免疫抑制增加,先前存在的 IBD 的病程在原位肝移植(OLT)后应该会改善。我们报告了一例尽管接受三联免疫抑制和美沙拉嗪治疗仍发生急性暴发性结肠炎的患者,并回顾了相关文献。

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