Chen Yingchao, He Yuanping, Zhang Shaorong, Li Lixiang, Zhu Xinhua, Liu Yuehui
Department of Otolaryngology Head and Neck Surgery, the Central Hospital of Xiaogan, Xiaogan, 432100, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jun;23(12):539-41, 545.
To investigate the expression and clinical significance of oncogene AKT2 in laryngeal squamous cell carcinoma (LSCC).
The expression of AKT2 protein was measured with immunohistochemistry (Elivision two steps) in 60 cases of LSCC tissue, 28 cases of peri-cancer tissue and 16 cases of normal laryngeal epithelium, the relationship between AKT2 expression and clinical pathologic factors in LSCC was also analyzed.
The positive rates of AKT2 protein expression in LSCC and peri-cancer tissue were 56.7% (34/60), 14.3% (4/28) respectively. There was no expression of AKT2 in normal laryngeal epithelium. The positive rate of AKT2 protein expression in LSCC was significantly higher than that in peri-cancer tissue and normal laryngeal epithelium (P < 0.05, respectively). The positive rate of AKT2 was correlated with tumor site, lymph node metastasis and clinical stage of LSCC (P < 0.05, respectively), but wasn't correlated with patient's age, sex, and T stage (P > 0.05, respectively).
AKT2 might play an important role in the tumorigenesis and development of LSCC, and it was suggested that AKT2 could be a useful marker for predicting tumorigenesis, invasion and metastasis potential of LSCC.
探讨癌基因AKT2在喉鳞状细胞癌（LSCC）中的表达及临床意义。
采用免疫组织化学（Elivision两步法）检测60例喉鳞状细胞癌组织、28例癌旁组织及16例正常喉上皮组织中AKT2蛋白的表达情况，并分析AKT2表达与喉鳞状细胞癌临床病理因素的关系。
喉鳞状细胞癌组织及癌旁组织中AKT2蛋白表达阳性率分别为56.7%（34/60）、14.3%（4/28）。正常喉上皮组织中未检测到AKT2表达。喉鳞状细胞癌组织中AKT2蛋白表达阳性率显著高于癌旁组织及正常喉上皮组织（P均<0.05）。AKT2阳性率与喉鳞状细胞癌的肿瘤部位、淋巴结转移及临床分期相关（P均<0.05），但与患者年龄、性别及T分期无关（P均>0.05）。
AKT2可能在喉鳞状细胞癌的发生发展中起重要作用，提示AKT2可作为预测喉鳞状细胞癌发生、侵袭及转移潜能的有用标志物。
