Dmitriev L F
Mol Biol (Mosk). 1990 Mar-Apr;24(2):566-71.
Malonic dialdehyde (MDA) crosslinking of complementary chains of DNA is suggested. It contributes to the stabilization of the DNA helix, making its replication impossible. MDA is considered as a cell division inhibitor. The MDA-producing process (lipid peroxidation) is considered to be a normal strictly controlled in vivo process. Control of rest and proliferation alternations in normal cells and its impairment in transformed cells are discussed in terms of the proposed idea.
有人提出，丙二醛（MDA）会使DNA互补链发生交联。这有助于DNA螺旋结构的稳定，使其无法复制。MDA被认为是一种细胞分裂抑制剂。产生MDA的过程（脂质过氧化）被认为是体内一个正常且受到严格控制的过程。基于这一观点，讨论了正常细胞中静止与增殖交替的控制以及转化细胞中这种控制的受损情况。
